Shabani Amir, Ahmadzad-Asl Masoud, Zangeneh Kambiz, Teimurinejad Samaneh, Kokar Sadaf, Taban Mojgan, Shariati Behnam, Mousavi Behbahani Zohreh, Ghasemzadeh Mohammadreza, Hasani Sahar, Nohesara Shabnam, Tat Somayyeh, Shirkhoda Shahabali, Ghorbani Zahra, Shariat Seyed Vahid
Department of Psychiatry, Mental Health Research Center, Iran University of Medical Sciences, Tehran, Iran.
Acta Med Iran. 2013 Jul 13;51(6):386-93.
Bipolar I disorder (BID) and its treatments have shown to be associated with deep impacts on patients' subjective feelings and quality of life (QOL). There are also some comments about impact of these feelings on course and outcome of patients with BID. This study was aimed to evaluate quality of life in patients with BID and to assess its relationship with course of disorder. Fifty patients with BID were recruited based on the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I) from May 2008 and followed for 12 months. Quality of life and mood disorder recurrence were assessed through World Health Organization Quality of Life and SCID-I tools respectively at baseline and after 6 and 12 months. Repeated measures analysis and logistic regression were used to analyze the independent effect of QOL and demographic factors on BID recurrence. Fifty patients (66% male; 48% never married; 48% in primary school level) with mean ± SE age and age of BID onset 33.8±1.5 and 26.6±1.1 years were studied. They had 3.4±0.6 episodes already. Twenty eight percent suffered from recurrences during the follow-up. The QOL scores at baseline, after 6 and 12 months were 70±1.8, 69.6±1.1 and 73±1.3 respectively. There were no significant change in QOL and its sub-domains during the follow-up (P=0.37). QOL showed no independent relationship with BID recurrences (P>0.1). No change in the QOL during the follow-up could denote lack of effectiveness of routine interventions on this factor. Also, short-term follow-up might be concerned as the possible reason. Of prime importance is to consider quality of life independently in treating patients with bipolar disorder.
双相 I 型障碍（BID）及其治疗方法已显示出对患者主观感受和生活质量（QOL）有深刻影响。也有一些关于这些感受对双相 I 型障碍患者病程和结局影响的评论。本研究旨在评估双相 I 型障碍患者的生活质量，并评估其与疾病病程的关系。根据《精神疾病诊断与统计手册》第四版轴 I 障碍的结构化临床访谈（SCID-I），从 2008 年 5 月开始招募了 50 名双相 I 型障碍患者，并对其进行了 12 个月的随访。分别在基线、6 个月和 12 个月时，通过世界卫生组织生活质量量表和 SCID-I 工具评估生活质量和情绪障碍复发情况。采用重复测量分析和逻辑回归分析生活质量和人口统计学因素对双相 I 型障碍复发的独立影响。研究了 50 名患者（66%为男性；48%从未结婚；48%为小学文化程度），其平均±标准误年龄和双相 I 型障碍发病年龄分别为 33.8±1.5 岁和 26.6±1.1 岁。他们已经有 3.4±0.6 次发作。28%的患者在随访期间复发。基线、6 个月和 12 个月时的生活质量得分分别为 70±1.8、69.6±1.1 和 73±1.3。随访期间生活质量及其子领域无显著变化（P = 0.37）。生活质量与双相 I 型障碍复发无独立关系（P>0.1）。随访期间生活质量无变化可能表明常规干预对该因素缺乏有效性。此外，短期随访可能也是一个原因。在治疗双相情感障碍患者时，最重要的是要独立考虑生活质量。
