Department of Community Health Nursing, Shimane University Faculty of Medicine, Izumo, Shimane, 693-8501, Japan.
J Clin Sleep Med. 2013 Jul 15;9(7):649-54. doi: 10.5664/jcsm.2828.
Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors that promote the growth and survival of neurons. Recent evidence suggests that BDNF is a sleep regulatory substance that contributes to sleep behavior. However, no studies have examined the association between the serum BDNF levels and dyssomnia. The present study was conducted to clarify the association between the serum BDNF levels and dyssomnia.
A total of 344 workers (age: 40.1 ± 10.5 years, male: 204, female: 140) were included in the study. The serum BDNF levels were categorized into tertiles according to sex.
The prevalence of dyssomnia was 35.1% in males and 30.0% in females. In the females, the BDNF levels were found to be negatively associated with dyssomnia after adjusting for age, body mass index, hypertension, dyslipidemia, hyperglycemia, depression, smoking, alcohol intake, and regular exercise. Compared with the females in the high BDNF group, the multivariate odds ratio (95% CI) of dyssomnia was 2.08 (0.62-6.98) in females in the moderate BDNF group and 8.41 (2.05-27.14) in females in the low BDNF group. No such relationships were found in the males.
The serum BDNF levels are associated with dyssomnia in Japanese female, but not male, workers.
脑源性神经营养因子（BDNF）是神经营养因子家族中的一种生长因子，可促进神经元的生长和存活。最近的证据表明，BDNF 是一种睡眠调节物质，有助于睡眠行为。然而，尚无研究探讨血清 BDNF 水平与失眠之间的关系。本研究旨在阐明血清 BDNF 水平与失眠之间的关系。
共纳入 344 名工人（年龄：40.1±10.5 岁，男性：204 人，女性：140 人）。根据性别将血清 BDNF 水平分为三分位。
男性失眠的患病率为 35.1%，女性为 30.0%。在女性中，调整年龄、体重指数、高血压、血脂异常、高血糖、抑郁、吸烟、饮酒和规律运动后，发现 BDNF 水平与失眠呈负相关。与高 BDNF 组女性相比，BDNF 水平中等的女性失眠的多变量比值比（95%CI）为 2.08（0.62-6.98），BDNF 水平低的女性失眠的多变量比值比（95%CI）为 8.41（2.05-27.14）。在男性中未发现这种关系。
血清 BDNF 水平与日本女性工人的失眠有关，但与男性工人无关。
