Pezé P, Mounier M, Cevallos R, Denis F
Service de Chirurgie Générale B, CHU Dupuytren, Limoges.
Pathol Biol (Paris). 1990 Jun;38(5 ( Pt 2)):504-7.
A study was performed to investigate the intraperitoneal penetration of Imipenem/cilastatin into inflammatory peritoneal fluid. Six patients undergoing abdominal surgery (acute peritonitis), were treated with Imipenem/cilastatin (4 perfusions of 0.5 g/day) during 5 days after the intervention. Plasma samples were obtained on day 1 and 4 at the pic and at the valley; peritoneal samples were obtained every days for 4 days, 1, 3 and 6 hours after the end of a perfusion. The samples were immediately stabilised following the manufacturer instructions and quick freezed at -80 degrees C. Dosages were performed using a microbiological assay. The mean peritoneal levels are above the MIC 90 of the more frequent bacteria which cause infection in abdominal surgery. Moreover none of the patients showed relapse of infection or complication during this treatment.
进行了一项研究以调查亚胺培南/西司他丁在炎症性腹水中的腹腔渗透情况。六名接受腹部手术（急性腹膜炎）的患者在干预后的5天内接受亚胺培南/西司他丁治疗（每天4次灌注，每次0.5克）。在第1天和第4天的峰浓度和谷浓度时采集血浆样本；在灌注结束后的1、3和6小时，连续4天每天采集腹水样本。按照制造商的说明立即对样本进行稳定处理，并快速冷冻至-80摄氏度。使用微生物测定法进行剂量测定。腹水平均浓度高于腹部手术中引起感染的常见细菌的MIC90。此外，在此治疗期间，没有患者出现感染复发或并发症。
