Leibler S, Maggs A C
Service de Physique Théorique de Saclay, Laboratoire de l'Institut de Recherche Fondamentale du Commissariat a l'Energie Atomique, Gif-sur-Yvette, France.
Proc Natl Acad Sci U S A. 1990 Aug;87(16):6433-5. doi: 10.1073/pnas.87.16.6433.
We present simulations of a model of a closed membrane that shares important features with erythrocytes: resistance to bending and shear, membrane asymmetry, and an osmotic pressure difference between the interior and exterior. By varying a few parameters we obtain several realistic (e.g., biconcave and cup-like) shapes whose fluctuations, analogous to flickering of erythrocytes, and mutual transformations are studied in thermal equilibrium. Our simulations form a basis for quantitative analysis of recent experiments done on erythrocytes and artificial bilayer vesicles. They also predict effects that could be observed in experiments such as an "'unbinding" phenomenon, i.e., a separation of adhering cells induced by thermal fluctuations.
我们展示了一个封闭膜模型的模拟结果，该模型与红细胞具有重要的共同特征：抗弯曲和抗剪切性、膜不对称性以及内部和外部之间的渗透压差异。通过改变几个参数，我们获得了几种逼真的（例如双凹形和杯状）形状，研究了它们在热平衡状态下类似于红细胞闪烁的波动以及相互转变。我们的模拟为近期对红细胞和人工双层囊泡所做实验的定量分析奠定了基础。它们还预测了在实验中可能观察到的效应，例如“解绑”现象，即由热涨落引起的黏附细胞的分离。
