产 KPC、多药耐药肺炎克雷伯菌 258 型，作为一种典型的机会性病原体。
KPC-producing, multidrug-resistant Klebsiella pneumoniae sequence type 258 as a typical opportunistic pathogen.
机构信息
Department of Microbiology, Medical School, University of Athens.
出版信息
Antimicrob Agents Chemother. 2013 Oct;57(10):5144-6. doi: 10.1128/AAC.01052-13. Epub 2013 Jul 15.
Abstract
The virulence of a KPC-producing Klebsiella pneumoniae sequence type 258 (ST258) strain representing those circulating in Greece was assessed in a mouse septicemia model. The strain was virtually avirulent (50% lethal dose, >10(8) and 5 × 10(7) CFU for immunocompetent and neutropenic animals, respectively). Also, it was highly susceptible to serum killing, rapidly phagocytosed in vitro, and classified as K41, which is not among the virulent capsular types. The findings indirectly support the notion that high ST258-associated mortality is largely due to inefficient antimicrobial treatment.
摘要
一种在希腊流行的产 KPC 肺炎克雷伯菌序列型 258（ST258）菌株的毒力在小鼠败血症模型中进行了评估。该菌株几乎没有毒力（免疫功能正常和中性粒细胞减少动物的 50%致死剂量分别为>10(8)和 5 × 10(7)CFU）。此外，它对血清杀伤高度敏感，在体外迅速被吞噬，并被分类为 K41，这不属于毒力荚膜类型。这些发现间接支持了这样一种观点，即高 ST258 相关死亡率主要归因于抗菌治疗效果不佳。
相似文献
1
KPC-producing, multidrug-resistant Klebsiella pneumoniae sequence type 258 as a typical opportunistic pathogen.产 KPC、多药耐药肺炎克雷伯菌 258 型，作为一种典型的机会性病原体。
Antimicrob Agents Chemother. 2013 Oct;57(10):5144-6. doi: 10.1128/AAC.01052-13. Epub 2013 Jul 15.
2
Quantification and comparison of virulence and characteristics of different variants of carbapenemase-producing Klebsiella pneumoniae clinical isolates from Taiwan and the United States.台湾和美国产碳青霉烯酶肺炎克雷伯菌临床分离株不同变体的毒力及特征的定量与比较
J Microbiol Immunol Infect. 2016 Feb;49(1):83-90. doi: 10.1016/j.jmii.2015.08.011. Epub 2015 Sep 9.
3
Draft genome sequence of an extremely drug-resistant KPC-producing Klebsiella pneumoniae ST258 epidemic strain.产 KPC 超耐药肺炎克雷伯菌 ST258 流行株的基因组草图序列
J Bacteriol. 2012 Nov;194(21):6014. doi: 10.1128/JB.01546-12.
4
In vitro and in vivo bactericidal activity of ceftazidime-avibactam against Carbapenemase-producing .头孢他啶-阿维巴坦对产碳青霉烯酶的. 的体外和体内杀菌活性。
Antimicrob Resist Infect Control. 2018 Nov 21;7:142. doi: 10.1186/s13756-018-0435-9. eCollection 2018.
5
Emergence of pan-resistance in KPC-2 carbapenemase-producing Klebsiella pneumoniae in Crete, Greece: a close call.希腊克里特岛产KPC-2碳青霉烯酶肺炎克雷伯菌泛耐药性的出现：千钧一发。
J Antimicrob Chemother. 2016 May;71(5):1207-12. doi: 10.1093/jac/dkv467. Epub 2016 Jan 26.
6
Emergence of clonally related Klebsiella pneumoniae isolates of sequence type 258 producing plasmid-mediated KPC carbapenemase in Norway and Sweden.挪威和瑞典出现序列型258的克隆相关肺炎克雷伯菌分离株，这些分离株产生质粒介导的KPC碳青霉烯酶。
J Antimicrob Chemother. 2009 Apr;63(4):654-8. doi: 10.1093/jac/dkp018. Epub 2009 Feb 13.
7
Outbreak of KPC-3-producing, and colistin-resistant, Klebsiella pneumoniae infections in two Sicilian hospitals.两家西西里医院爆发产 KPC-3、耐黏菌素肺炎克雷伯菌感染。
Clin Microbiol Infect. 2011 Sep;17(9):1444-7. doi: 10.1111/j.1469-0691.2011.03572.x. Epub 2011 Jun 10.
8
Bloodstream infections caused by metallo-β-lactamase/Klebsiella pneumoniae carbapenemase-producing K. pneumoniae among intensive care unit patients in Greece: risk factors for infection and impact of type of resistance on outcomes.希腊重症监护病房患者中产金属β-内酰胺酶/肺炎克雷伯菌碳青霉烯酶的肺炎克雷伯菌引起的血流感染：感染的危险因素和耐药类型对结局的影响。
Infect Control Hosp Epidemiol. 2010 Dec;31(12):1250-6. doi: 10.1086/657135. Epub 2010 Oct 25.
9
The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria.产肺炎克雷伯菌碳青霉烯酶细菌的真正威胁。
Lancet Infect Dis. 2009 Apr;9(4):228-36. doi: 10.1016/S1473-3099(09)70054-4.
10
Identification of a KPC-9-producing Klebsiella pneumoniae ST258 cluster among KPC-2-producing isolates of an ongoing outbreak in Northwestern Greece: a retrospective study.在希腊西北部持续爆发的产KPC-2肺炎克雷伯菌分离株中鉴定出一个产KPC-9的肺炎克雷伯菌ST258克隆群：一项回顾性研究
Clin Microbiol Infect. 2018 May;24(5):558-560. doi: 10.1016/j.cmi.2017.12.007. Epub 2017 Dec 21.
引用本文的文献
1
Best Practices in the Development and Use of Experimental Models of Bacterial Pneumonia: An Official American Thoracic Society Workshop Report.细菌性肺炎实验模型开发与应用的最佳实践：美国胸科学会官方研讨会报告
Am J Respir Cell Mol Biol. 2025 Aug;73(2):178-199. doi: 10.1165/rcmb.2025-0322ST.
2
liver abscesses: pathogenesis, treatment, and ongoing challenges.肝脓肿：发病机制、治疗及当前挑战
Infect Immun. 2025 Aug 12;93(8):e0050824. doi: 10.1128/iai.00508-24. Epub 2025 Jul 3.
3
In Vivo Evolution of a Klebsiella pneumoniae Capsule Defect With wcaJ Mutation Promotes Complement-Mediated Opsonophagocytosis During Recurrent Infection.在复发性感染过程中，携带 wcaJ 突变的肺炎克雷伯菌荚膜缺陷的体内进化促进补体介导的调理吞噬作用。
J Infect Dis. 2024 Jul 25;230(1):209-220. doi: 10.1093/infdis/jiae003.
4
Virulence Factors in : A Literature Review.《中的毒力因子：文献综述》
（注：原文中“Virulence Factors in :”表述不完整，这里根据常规推测补充了冒号后的内容，比如可能是某个具体领域，但由于原文缺失信息只能这样处理使译文尽量通顺。）
Indian J Microbiol. 2024 Jun;64(2):389-401. doi: 10.1007/s12088-024-01247-0. Epub 2024 Mar 27.
5
Genomic insights unveil the plasmid transfer mechanism and epidemiology of hypervirulent Klebsiella pneumoniae in Vietnam.基因组研究揭示了越南高毒力肺炎克雷伯菌的质粒转移机制和流行病学特征。
Nat Commun. 2024 May 17;15(1):4187. doi: 10.1038/s41467-024-48206-3.
6
Subinhibitory antibiotic concentrations promote the excision of a genomic island carried by the globally spread carbapenem-resistant sequence type 258.亚抑菌浓度的抗生素会促进在全球传播的碳青霉烯类耐药 258 型序列中携带的基因组岛的切除。
Microb Genom. 2023 Dec;9(12). doi: 10.1099/mgen.0.001138.
7
Genetic Characterization of Carbapenem-Resistant Clinical Isolates in a Tertiary Hospital in Greece, 2018-2022.2018 - 2022年希腊一家三级医院耐碳青霉烯临床分离株的基因特征分析
Antibiotics (Basel). 2023 May 28;12(6):976. doi: 10.3390/antibiotics12060976.
8
Phagocytosis is a primary determinant of pulmonary clearance of clinical isolates.吞噬作用是临床分离株肺部清除的主要决定因素。
Front Cell Infect Microbiol. 2023 Mar 28;13:1150658. doi: 10.3389/fcimb.2023.1150658. eCollection 2023.
9
Carbapenem-Resistant : Virulence Factors, Molecular Epidemiology and Latest Updates in Treatment Options.耐碳青霉烯类：毒力因子、分子流行病学及治疗选择的最新进展
Antibiotics (Basel). 2023 Jan 21;12(2):234. doi: 10.3390/antibiotics12020234.
10
Phylogenetic analysis and characterization of arsenic (As) transforming bacterial marker proteins following isolation of As-tolerant indigenous bacteria.砷（As）耐受土著菌分离后，对砷转化细菌标记蛋白进行系统发育分析和特性研究。
Arch Microbiol. 2022 Oct 3;204(11):660. doi: 10.1007/s00203-022-03270-5.
本文引用的文献
1
Measurement of phagocytosis, phagosome acidification, and intracellular killing of Staphylococcus aureus.金黄色葡萄球菌吞噬作用、吞噬体酸化及细胞内杀伤的测量。
Curr Protoc Immunol. 2012 Nov;Chapter 14:14.30.1-14.30.12. doi: 10.1002/0471142735.im1430s99.
2
Unique genes identified in the epidemic extremely drug-resistant KPC-producing Klebsiella pneumoniae sequence type 258.在流行的产极耐药 KPC 肺炎克雷伯菌 258 型序列中鉴定出的独特基因。
J Antimicrob Chemother. 2013 Jan;68(1):74-83. doi: 10.1093/jac/dks370. Epub 2012 Oct 4.
3
Carbapenemases in Klebsiella pneumoniae and other Enterobacteriaceae: an evolving crisis of global dimensions.肺炎克雷伯菌和其他肠杆菌科细菌中的碳青霉烯酶：具有全球范围的不断演变的危机。
Clin Microbiol Rev. 2012 Oct;25(4):682-707. doi: 10.1128/CMR.05035-11.
4
Emergence of carbapenem-resistant Enterobacteriaceae as causes of bloodstream infections in patients with hematologic malignancies.碳青霉烯类耐药肠杆菌科细菌作为血液恶性肿瘤患者血流感染的病因出现。
Leuk Lymphoma. 2013 Apr;54(4):799-806. doi: 10.3109/10428194.2012.723210. Epub 2012 Sep 14.
5
Asymptomatic rectal carriage of blaKPC producing carbapenem-resistant Enterobacteriaceae: who is prone to become clinically infected?产 blaKPC 碳青霉烯类耐药肠杆菌科无症状直肠携带：哪些人易发生临床感染？
Clin Microbiol Infect. 2013 May;19(5):451-6. doi: 10.1111/j.1469-0691.2012.03888.x. Epub 2012 May 7.
6
Virulence and plasmid transferability of KPC Klebsiella pneumoniae at the Veterans Affairs Healthcare System of New Jersey.新泽西州退伍军人事务医疗保健系统中 KPC 肺炎克雷伯菌的毒力和质粒可转移性。
Microb Drug Resist. 2012 Aug;18(4):380-4. doi: 10.1089/mdr.2011.0241. Epub 2012 Apr 25.
7
Risk factors for developing clinical infection with carbapenem-resistant Klebsiella pneumoniae in hospital patients initially only colonized with carbapenem-resistant K pneumoniae.耐碳青霉烯类肺炎克雷伯菌定植患者中发生耐碳青霉烯类肺炎克雷伯菌临床感染的危险因素。
Am J Infect Control. 2012 Jun;40(5):421-5. doi: 10.1016/j.ajic.2011.05.022. Epub 2011 Sep 9.
8
Klebsiella pneumoniae yersiniabactin promotes respiratory tract infection through evasion of lipocalin 2.肺炎克雷伯菌耶尔森菌素通过逃避脂钙蛋白 2 促进呼吸道感染。
Infect Immun. 2011 Aug;79(8):3309-16. doi: 10.1128/IAI.05114-11. Epub 2011 May 16.
9
Risk factors and clinical impact of Klebsiella pneumoniae carbapenemase-producing K. pneumoniae.产碳青霉烯酶肺炎克雷伯菌的危险因素和临床影响。
Infect Control Hosp Epidemiol. 2009 Dec;30(12):1180-5. doi: 10.1086/648451.
10
Virulent clones of Klebsiella pneumoniae: identification and evolutionary scenario based on genomic and phenotypic characterization.肺炎克雷伯菌的毒力克隆：基于基因组和表型特征的鉴定及进化情况
PLoS One. 2009;4(3):e4982. doi: 10.1371/journal.pone.0004982. Epub 2009 Mar 25.
Zotero 插件