与金属有机钌药效团络合增强了 4-苯胺基喹唑啉诱导细胞凋亡的能力。
Complexation with organometallic ruthenium pharmacophores enhances the ability of 4-anilinoquinazolines inducing apoptosis.
机构信息
Beijing National Laboratory for Molecular Sciences, Beijing 100190, PR China.
出版信息
Chem Commun (Camb). 2013 Nov 11;49(87):10224-6. doi: 10.1039/c3cc43000f.
PMID:23856988
Abstract
The complexation with organoruthenium fragments confers 4-anilinoquinazoline pharmacophores with higher potential for inducing cellular apoptosis while the highly inhibitory activity of 4-anilinoquinazolines against EGFR and the reactivity of the ruthenium centre to 9-ethylguanine are well preserved.
摘要
有机钌片段的络合使 4-苯胺喹唑啉药效团具有更高的诱导细胞凋亡的潜力，同时 4-苯胺喹唑啉对 EGFR 的高度抑制活性和钌中心对 9-乙基鸟嘌呤的反应性得以很好地保留。
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