Tobiishi Kazuhiro, Suzuki Shigeru, Todaka Takashi, Hirakawa Hironori, Hori Tsuguhide, Kajiwara Jumboku, Hirata Teruaki, Iida Takao, Uchi Hiroshi, Furue Masutaka
Fukuoka Institute of Health and Environmental Sciences, 39 Mukaizano, Dazaifu, Fukuoka 818-0135, Japan.
Fukuoka Igaku Zasshi. 2013 Apr;104(4):136-42.
Hydroxylated polychlorinated biphenyls (OH-PCBs) are formed as major metabolites of PCBs by cytochrome P450 enzyme-mediated oxidation. It has been reported that their total concentration in serum samples of Yusho patients ranged from 390 to 1300 pg/g. We measured the concentration of OH-PCBs in blood collected from 183 Yusho patients living in Japan in 2010. The major OH-PCB metabolites were 4-OH-CB187 (ND-1300 pg/g-wet), 4-OH-CB146 + 3-OH-CB153 (8.4-1200 pg/g-wet), 4-OH-CB109 (ND-530 pg/g-wet) and 4'-OH-CB172 (ND-380 pg/g-wet). The total OH-PCBs ranged from 36 to 3800 pg/g-wet. A positive relationship between the concentrations of OH-PCBs and PCBs was observed, but no significant relationship between the concentrations of OH-PCBs and PCDD/DFs was observed.
羟基化多氯联苯（OH-PCBs）是多氯联苯经细胞色素P450酶介导氧化形成的主要代谢产物。据报道，油症患者血清样本中它们的总浓度在390至1300 pg/g之间。我们测定了2010年从居住在日本的183名油症患者采集的血液中OH-PCBs的浓度。主要的OH-PCB代谢产物为4-OH-CB187（未检出-1300 pg/g湿重）、4-OH-CB146 + 3-OH-CB153（8.4-1200 pg/g湿重）、4-OH-CB109（未检出-530 pg/g湿重）和4'-OH-CB172（未检出-380 pg/g湿重）。OH-PCBs的总浓度在36至3800 pg/g湿重之间。观察到OH-PCBs浓度与多氯联苯浓度之间呈正相关，但未观察到OH-PCBs浓度与多氯二苯并对二噁英/多氯二苯并呋喃（PCDD/DFs）浓度之间存在显著相关性。
