Otsuka Nobuko, Miyashita Kotaro, Krieger Derk W, Naritomi Hiroaki
Neurology Division, Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Japan.
Front Neurol Neurosci. 2013;32:45-53. doi: 10.1159/000348821. Epub 2013 Jul 8.
Stroke is a leading cause of long-term disability with early accelerated followed by gradual recovery during the first 6 months after the ictus. The most important mechanism concerning early recovery is thought to be brain plasticity provided by anatomical and functional reorganization of the central nervous system after injury. Recent advances in noninvasive, functional brain imaging techniques provided some insight indicating the contribution of ipsilateral uncrossed corticospinal tracts in motor recovery after stroke. Since motor tracts vary considerably among subjects, the ratio of contralateral corticospinal tract fibers and their interhemispheric control versus the amount and function of ipsilateral corticospinal tract fibers may affect the scale of motor recovery after stroke. Further studies are needed to clarify the mechanisms of motor recovery after stroke in humans.
中风是导致长期残疾的主要原因，在发病后的头6个月内，早期恢复加速，随后逐渐恢复。关于早期恢复的最重要机制被认为是损伤后中枢神经系统的解剖和功能重组所提供的脑可塑性。非侵入性脑功能成像技术的最新进展提供了一些见解，表明同侧未交叉的皮质脊髓束在中风后运动恢复中的作用。由于运动束在个体之间差异很大，对侧皮质脊髓束纤维的比例及其半球间控制与同侧皮质脊髓束纤维的数量和功能可能会影响中风后运动恢复的程度。需要进一步研究以阐明人类中风后运动恢复的机制。
