1] Laboratoire de Génétique Moléculaire Humaine, Département de Recherche Scientifique, Institut Pasteur du Maroc, Casablanca, Morocco [2] Laboratoire d'Agroalimentaire et Santé, Faculté des Sciences et Techniques, Université Hassan I, Settat, Morocco.
Laboratoire de Génétique Moléculaire Humaine, Département de Recherche Scientifique, Institut Pasteur du Maroc, Casablanca, Morocco.
Eur J Hum Genet. 2014 Mar;22(3):322-6. doi: 10.1038/ejhg.2013.151. Epub 2013 Jul 17.
National and ethnic mutation databases provide comprehensive information about genetic variations reported in a population or an ethnic group. In this paper, we present the Moroccan Genetic Disease Database (MGDD), a catalogue of genetic data related to diseases identified in the Moroccan population. We used the PubMed, Web of Science and Google Scholar databases to identify available articles published until April 2013. The Database is designed and implemented on a three-tier model using Mysql relational database and the PHP programming language. To date, the database contains 425 mutations and 208 polymorphisms found in 301 genes and 259 diseases. Most Mendelian diseases in the Moroccan population follow autosomal recessive mode of inheritance (74.17%) and affect endocrine, nutritional and metabolic physiology. The MGDD database provides reference information for researchers, clinicians and health professionals through a user-friendly Web interface. Its content should be useful to improve researches in human molecular genetics, disease diagnoses and design of association studies. MGDD can be publicly accessed at http://mgdd.pasteur.ma.
国家和民族突变数据库提供了有关人群或族群中报告的遗传变异的全面信息。本文介绍了摩洛哥遗传疾病数据库（MGDD），这是一个与在摩洛哥人群中发现的疾病相关的遗传数据目录。我们使用 PubMed、Web of Science 和 Google Scholar 数据库来确定截至 2013 年 4 月发布的可用文章。该数据库使用 MySQL 关系数据库和 PHP 编程语言设计和实现了一个三层模型。迄今为止，该数据库包含 301 个基因和 259 种疾病中的 425 种突变和 208 种多态性。摩洛哥人群中的大多数孟德尔疾病遵循常染色体隐性遗传模式（74.17%），并影响内分泌、营养和代谢生理学。MGDD 数据库通过用户友好的 Web 界面为研究人员、临床医生和卫生专业人员提供参考信息。其内容有助于改善人类分子遗传学研究、疾病诊断和关联研究的设计。MGDD 可在 http://mgdd.pasteur.ma 上公开访问。
