Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Neurol India. 2013 May-Jun;61(3):226-30. doi: 10.4103/0028-3886.115056.
Gluten sensitivity (GS) is a spectrum of disorders with diverse manifestations. Recent evidence suggests that ataxia may be the only manifestation of GS and that it may be one of the causes of sporadic ataxia.
To investigate the prevalence of gluten ataxia among patients with ataxia in China.
Serum levels of anti-gliadin, anti-transglutaminase 2 (TG2), and anti-transglutaminase 6 (TG6) antibodies measured in 125 patients with ataxia (100 patients with sporadic ataxia and 25 patients with hereditary ataxia) and 51 healthy controls by enzyme-linked immunosorbent assay (ELISA).
The serum concentrations of anti-gliadin, anti-TG2 IgG, IgA, and TG6-IgG antibodies were elevated in ataxia patients, but the increase was not statistically significant. However, TG6-IgA serum levels were significantly higher in sporadic ataxia as compared to those in healthy controls (P < 0.05).
These results provide evidence that sporadic ataxia in a subgroup of patients may be due to gluten ataxia in mainland China. Measurement of serum anti-TG6 antibodies along with anti-TG2 and anti-gliadin antibodies may be useful for diagnosing gluten ataxia.
麸质敏感性（GS）是一种具有多种表现形式的疾病谱。最近的证据表明，共济失调可能是 GS 的唯一表现形式，并且它可能是散发性共济失调的原因之一。
调查中国共济失调患者中麸质相关性共济失调的患病率。
采用酶联免疫吸附试验（ELISA）检测 125 例共济失调患者（100 例散发性共济失调患者和 25 例遗传性共济失调患者）和 51 例健康对照者血清抗麦胶蛋白、抗转谷氨酰胺酶 2（TG2）和抗转谷氨酰胺酶 6（TG6）抗体水平。
共济失调患者血清抗麦胶蛋白、抗 TG2 IgG、IgA 和 TG6-IgG 抗体浓度升高，但升高无统计学意义。然而，与健康对照组相比，散发性共济失调患者的血清 TG6-IgA 水平显著升高（P<0.05）。
这些结果提供了证据表明，中国内地部分患者的散发性共济失调可能是由于麸质相关性共济失调引起的。检测血清抗 TG6 抗体以及抗 TG2 和抗麦胶蛋白抗体可能有助于诊断麸质相关性共济失调。
