基于基因工程蛋白笼的纳米载体递送至人肝癌细胞的阿霉素。
A nanocarrier based on a genetically engineered protein cage to deliver doxorubicin to human hepatocellular carcinoma cells.
机构信息
Department of Advanced Medical Initiatives, Faculty of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Fukuoka 812-8582, Japan.
出版信息
Chem Commun (Camb). 2013 Aug 28;49(67):7442-4. doi: 10.1039/c3cc44508a.
PMID:23860596
Abstract
Herein, we report the preparation of genetically engineered protein cages (HspG41C-SP94), taken up selectively by human hepatocellular carcinoma (HCC) cells. An engineered protein cage-doxorubicin (DOX) conjugate was as cytotoxic as free DOX against HCC cells but much less cytotoxic against normal hepatocytes.
摘要
在此，我们报告了基因工程蛋白笼（HspG41C-SP94）的制备，该蛋白笼可被人肝癌（HCC）细胞选择性摄取。与游离 DOX 相比，工程蛋白笼-阿霉素（DOX）缀合物对 HCC 细胞的细胞毒性与其相当，但对正常肝细胞的细胞毒性要小得多。
Zotero 插件