Vidal Adriana C, Murtha Amy P, Murphy Susan K, Fortner Kimberly, Overcash Francine, Henry Nikki, Schildkraut Joellen M, Forman Michele R, Demark-Wahnefried Wendy, Kurtzberg Joanne, Jirtle Randy, Hoyo Cathrine
Department of Obstetrics and Gynecology and Program of Cancer Detection, Prevention and Control, Duke University School of Medicine, Durham, NC 27710, USA.
Int J Pediatr. 2013;2013:191472. doi: 10.1155/2013/191472. Epub 2013 Jun 3.
At birth, elevated IGF-I levels have been linked to birth weight extremes; high birth weight and low birth weight are risk factors for adult-onset chronic diseases including obesity, cardiovascular disease, and type 2 diabetes. We examined associations between plasma IGF-I levels and birth weight among infants born to African American and White obese and nonobese women. Prepregnancy weight and height were assessed among 251 pregnant women and anthropometric measurements of full term infants (≥37 weeks of gestation) were taken at birth. Circulating IGF-I was measured by ELISA in umbilical cord blood plasma. Linear regression models were utilized to examine associations between birth weight and high IGF-I, using the bottom two tertiles as referents. Compared with infants with lower IGF-I levels (≤3rd tertile), those with higher IGF-I levels (>3rd tertile) were 130 g heavier at birth, (β-coefficient = 230, se = 58.0, P = 0.0001), after adjusting for gender, race/ethnicity, gestational age, delivery route, maternal BMI and smoking. Stratified analyses suggested that these associations are more pronounced in infants born to African American women and women with BMI ≥30 kg/m(2); the cross product term for IGF-I and maternal BMI was statistically significant (P ≤ 0.0004). Our findings suggest that the association between IGF-I levels and birth weight depends more on maternal obesity than African American race/ethnicity.
出生时，胰岛素样生长因子-I（IGF-I）水平升高与出生体重极端情况有关；高出生体重和低出生体重是成人期慢性疾病（包括肥胖症、心血管疾病和2型糖尿病）的危险因素。我们研究了非裔美国人和白人肥胖及非肥胖女性所生婴儿的血浆IGF-I水平与出生体重之间的关联。对251名孕妇进行了孕前体重和身高评估，并在出生时对足月婴儿（≥37周妊娠）进行了人体测量。采用酶联免疫吸附测定法（ELISA）检测脐血血浆中的循环IGF-I。利用线性回归模型，以最低的两个三分位数为参照，研究出生体重与高IGF-I之间的关联。在调整了性别、种族/民族、胎龄、分娩方式、母亲体重指数和吸烟情况后，与IGF-I水平较低（≤第三个三分位数）的婴儿相比，IGF-I水平较高（>第三个三分位数）的婴儿出生时体重重130克，（β系数 = 230，标准误 = 58.0，P = 0.0001）。分层分析表明，这些关联在非裔美国女性和体重指数≥30 kg/m²的女性所生婴儿中更为明显；IGF-I与母亲体重指数的交叉乘积项具有统计学意义（P≤0.0004）。我们的研究结果表明，IGF-I水平与出生体重之间的关联更多地取决于母亲肥胖，而非非裔美国种族/民族。
