Pyszczynski Sarah J, Munson Eric J
Department of Pharmaceutical Sciences, University of Kentucky , Lexington, Kentucky 40536, United States.
Mol Pharm. 2013 Sep 3;10(9):3323-32. doi: 10.1021/mp400104b. Epub 2013 Aug 5.
We have identified and characterized a new solid form of trehalose, the δ form (Tδ) using (13)C solid-state NMR spectroscopy (SSNMR). Tδ is formed from dehydrations of trehalose dihydrate (T(h)) performed at or below 100 °C, and it is generated concurrently with the α form of trehalose (Tα) and amorphous trehalose (T(am)); the β form of trehalose (Tβ) has been observed in some dehydrated samples. Differential scanning calorimetry (DSC) and powder X-ray diffraction (PXRD) studies of samples containing Tδ do not indicate the presence of the new form. Tδ is metastable: upon exposure to temperatures above 80 °C, it converts to either Tα or Tam, and upon exposure to ambient humidity, it reverts to T(h).
