人可溶性鸟苷酸环化酶作为一氧化氮传感器用于 NO 信号转导揭示了亚硝酸盐还原酶的新功能。
Human soluble guanylate cyclase as a nitric oxide sensor for NO-signalling reveals a novel function of nitrite reductase.
机构信息
Department of Chemistry & Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China.
出版信息
Chem Commun (Camb). 2013 Aug 28;49(67):7454-6. doi: 10.1039/c3cc43321h.
Human soluble guanylate cyclase (hsGC), a NO sensor/NO receptor of a heterodimeric hemoprotein, plays a critical role in the NO-sGC-cGMP signaling pathway, and also reveals a novel nitrite reductase activity. This indicates that hsGC could activate itself by catalytic reduction of nitrite to NO instead of receiving NO from nitric oxide synthase (NOS), which provides valuable insight into the physiological function of the homodimeric hsGC.
人可溶性鸟苷酸环化酶（hsGC）是一种异二聚体血红素蛋白的 NO 传感器/NO 受体，在 NO-sGC-cGMP 信号通路中发挥着关键作用，同时也揭示了一种新型的亚硝酸盐还原酶活性。这表明 hsGC 可以通过催化还原亚硝酸盐生成 NO 来激活自身，而不是从一氧化氮合酶（NOS）接收 NO，这为同二聚体 hsGC 的生理功能提供了有价值的见解。
Zotero 插件