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利用耳软骨-软骨膜复合组织进行眼睑重建术治疗肿瘤病变。

Lower lid reconstruction utilizing auricular conchal chondral-perichondral tissue in patients with neoplastic lesions.

机构信息

Department of Plastic and Reconstructive Surgery, Azienda Ospedaliero-Universitaria "Santa Maria della Misericordia," Piazzale S. Maria della Misericordia 15, 33100 Udine, Italy.

出版信息

Biomed Res Int. 2013;2013:837536. doi: 10.1155/2013/837536. Epub 2013 Jun 20.

DOI:10.1155/2013/837536
PMID:23865069
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3705807/
Abstract

PURPOSE

To assess surgical outcomes of lower lid reconstruction surgery using auricular conchal tissue.

METHODS

This prospective study included 20 patients that underwent reconstructive lower lid surgery using autologous auricle chondral-perichondral graft tissue. Auricle tissue was used to provide adequate support and protection with similar conjunctiva tarsal structures on overlying soft tissues in patients with pathologic inferior lid tissue loss requiring reconstructive surgery. Biopsies with histopathology and cytology analysis were taken after 1 year. Cytology analysis using CK19 was used to confirm newly formed conjunctiva overlying the graft.

RESULTS

All patients showed no graft rejection. Surgical outcomes were generally good, with minimal or no ocular complications. 16 of 20 patients had excellent results, showing good lid symmetry and esthetics, minimal auricular discomfort, patient satisfaction and proper lid function. Surgical outcomes were highly dependent on proper post-op conjunctiva formation. All patients were positive for CK19, thus indicating proper conjunctiva tissue formation.

CONCLUSIONS

Lower lid reconstruction surgery using auricular chondral-perichondral conchal tissue is a good alternative in patients with neoplastic lesions. Autologous chondral-perichondral tissue provides good functional and mechanical support in the reconstructed lid, thus reducing the risks of ectropion and corneal exposure and ensuring a protected ocular surface.

摘要

目的

评估使用耳软骨-软骨膜组织进行下眼睑重建手术的效果。

方法

本前瞻性研究纳入了 20 例接受自体耳软骨-软骨膜移植物修复下眼睑手术的患者。当患有病理性下眼睑组织缺失的患者需要进行重建手术时，耳软骨组织可以提供足够的支撑和保护，同时覆盖在其上的软组织与相似的结膜睑板结构相匹配。术后 1 年进行活检，进行组织病理学和细胞学分析。使用 CK19 进行细胞学分析，以确认移植物上形成的新结膜。

结果

所有患者均未发生移植物排斥。手术效果总体良好，眼部并发症极少或无。20 例患者中有 16 例效果极佳，眼睑对称性和美观度良好，耳部不适感轻微，患者满意度高，眼睑功能正常。手术效果高度依赖于术后结膜的适当形成。所有患者 CK19 均为阳性，表明结膜组织形成良好。

结论

对于患有肿瘤病变的患者，使用耳软骨-软骨膜耳软骨组织进行下眼睑重建手术是一种较好的选择。自体软骨-软骨膜组织为重建的眼睑提供了良好的功能和机械支撑，从而降低了眼睑外翻和暴露性角膜的风险，并确保了眼部表面得到保护。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0f0/3705807/0cd00197433a/BMRI2013-837536.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0f0/3705807/40ac61a9bcfc/BMRI2013-837536.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0f0/3705807/1928e7928f6d/BMRI2013-837536.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0f0/3705807/0b1d0a7bec12/BMRI2013-837536.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0f0/3705807/05c975e29d07/BMRI2013-837536.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0f0/3705807/3d468ade4c48/BMRI2013-837536.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0f0/3705807/031c88105292/BMRI2013-837536.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0f0/3705807/0cd00197433a/BMRI2013-837536.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0f0/3705807/40ac61a9bcfc/BMRI2013-837536.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0f0/3705807/1928e7928f6d/BMRI2013-837536.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0f0/3705807/0b1d0a7bec12/BMRI2013-837536.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0f0/3705807/05c975e29d07/BMRI2013-837536.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0f0/3705807/3d468ade4c48/BMRI2013-837536.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0f0/3705807/031c88105292/BMRI2013-837536.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0f0/3705807/0cd00197433a/BMRI2013-837536.007.jpg

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