Orsal Ebru, Seven Bedri, Keles Mustafa, Ayan Arif Kursad, Cankaya Erdem, Ozkan Ozalkan
Department of Nuclear Medicine, Ataturk University, Erzurum, Turkey.
Hell J Nucl Med. 2013 May-Aug;16(2):107-10.
Chronic renal failure and its treatment can induce oral health problems and salivary glands dysfunction. The purpose of this study was to assess salivary glands function in patients with kidney transplantation using technetium-99m pertechnetate ((99m)Tc-P) salivary glands scintigraphy. We prospectively studied 34 patients with kidney transplantation (30 males and 4 females,mean age 39.76±11.6 years) and 28 healthy controls (12 males and 16 females, mean age 36.1±9.5 years). Salivary gland scintigraphy was performed nearly 4.4±2.9 years after successful kidney transplantation. Dynamic salivary glands scintigraphy was performed during 25min after the intravenous administration of 185MBq of (99m)Tc-P. Time-activity curves and glands functional parameters were calculated for the parotid and submandibular salivary glands: uptake ratio, maximum accumulation of the radionuclide, and excretion fraction. Statistical analysis of the functional parameters showed no significant differences between patients with kidney transplantation and healthy controls (P>0.05). In conclusion, this study showed that using (99m)Tc-P salivary gland scintigraphy, salivary glands function of patients with successful kidney transplantation do not differ statistically from those in healthy controls.
慢性肾衰竭及其治疗可引发口腔健康问题和唾液腺功能障碍。本研究的目的是利用锝-99m高锝酸盐（（99m）Tc-P）唾液腺闪烁扫描术评估肾移植患者的唾液腺功能。我们前瞻性地研究了34例肾移植患者（30例男性和4例女性，平均年龄39.76±11.6岁）和28例健康对照者（12例男性和16例女性，平均年龄36.1±9.5岁）。在肾移植成功后约4.4±2.9年进行唾液腺闪烁扫描。在静脉注射185MBq的（99m）Tc-P后25分钟内进行动态唾液腺闪烁扫描。计算腮腺和颌下唾液腺的时间-活性曲线和腺体功能参数：摄取率、放射性核素的最大蓄积量和排泄分数。对功能参数的统计分析显示，肾移植患者与健康对照者之间无显著差异（P>0.05）。总之，本研究表明，使用（99m）Tc-P唾液腺闪烁扫描术，肾移植成功患者的唾液腺功能与健康对照者在统计学上无差异。
