Richter C, Theus M, Schlegel J
Laboratory of Biochemistry I, Swiss Federal Institute of Technology, Zürich.
Biochem Pharmacol. 1990 Aug 15;40(4):779-82. doi: 10.1016/0006-2952(90)90315-c.
Mitochondria participate in the maintenance of cellular Ca2+ homeostasis. Here we show that the immunosuppressive drug cyclosporine A at low concentrations inhibits release but not uptake of Ca2+ by mitochondria. Prevention of Ca2+ release is due to inhibition of intramitochondrial enzymatic hydrolysis of NAD to ADP-ribose and nicotinamide. These findings suggest a mechanism by which cyclosporine A interferes with cellular Ca2+ homeostasis, and may be related to the immunosuppressive and cytotoxic properties of the drug.
线粒体参与维持细胞内钙离子稳态。在此我们表明，低浓度的免疫抑制药物环孢素A可抑制线粒体释放钙离子，但不影响其摄取钙离子。钙离子释放的抑制是由于线粒体内将烟酰胺腺嘌呤二核苷酸（NAD）酶解为二磷酸核糖腺苷（ADP - 核糖）和烟酰胺的过程受到抑制。这些发现提示了环孢素A干扰细胞钙离子稳态的一种机制，并且可能与该药物的免疫抑制和细胞毒性特性有关。
