Fink Susanne, Kunzmann Steffen, Andres Oliver, Eyrich Matthias, Wiegering Verena
University of Würzburg, Paediatric Intensive Care and Neonatology Unit, Children's Hospital , Germany and.
J Matern Fetal Neonatal Med. 2014 Apr;27(6):621-4. doi: 10.3109/14767058.2013.825600. Epub 2013 Aug 20.
Haemophiliacs and extremely premature infants are both at an increased risk for intracranial haemorrhage; both conditions might be further elevating the risk. We report a case of a very immature preterm-infant of 26 gestational weeks (birth weight 635 g) with severe haemophilia A. Furthermore, we provide an overview of the published literature on this subject matter. Until now, deficiency of factor VIII or IX as a potential risk factor for ICH in preterm infants remains controversial. However, prophylactic substitution of factor VIII or IX in preterm infants with haemophilia may minimize the risk of bleeding complications and neurologic sequelae.
血友病患者和极早产儿发生颅内出血的风险均会增加；这两种情况可能会进一步提高风险。我们报告了一例孕26周（出生体重635克）的极不成熟早产儿合并严重甲型血友病的病例。此外，我们还概述了关于这一主题的已发表文献。到目前为止，VIII因子或IX因子缺乏作为早产儿颅内出血的潜在危险因素仍存在争议。然而，对患有血友病的早产儿预防性补充VIII因子或IX因子可能会将出血并发症和神经后遗症的风险降至最低。
