CNS Spectr. 2013 Aug;18(4):171-4. doi: 10.1017/S109285291300045X.
Ketamine induces rapid-onset and short-duration improvement in depressive and suicidal symptoms in both treatment-resistant unipolar depression and bipolar depression, and also reduces chronic pain after short intravenous infusions. In order to develop long-acting oral agents with the same clinical effects, the pharmacologic mechanism of action must be understood, and the leading hypotheses are discussed here.
氯胺酮可迅速缓解治疗抵抗性单相和双相抑郁患者的抑郁和自杀症状，并在短时间静脉输注后减轻慢性疼痛。为了开发具有相同临床效果的长效口服制剂，必须了解其药理作用机制，本文讨论了主要假说。
