Bhulani Nizar, Khawaja Ali, Jafferani Asif, Baqir Maryam, Ebrahimi Ramin, Sajjad Zafar
Department of Medicine, Research Associate, Aga Khan University, Karachi, Pakistan.
BMC Res Notes. 2013 Jul 19;6:279. doi: 10.1186/1756-0500-6-279.
The need of having feasible screening tools like Coronary Calcium Scoring (CCS) and CT Coronary Artery (CTCA) for Coronary Artery Disease (CAD) has become paramount. We aimed to evaluate the accuracy of CCS in determining the degree of stenosis of coronary vessels as compared to that determined by CTCA in a South Asian population.
A retrospective study was conducted at The Aga Khan University Hospital. A total of 539 patient records were reviewed who had undergone CCS and CTCA between 2008 and 2010. Patient records were reviewed by comparing their CCS and CTCA results.
About 268 out of 301 (89%) patients with a CCS of 0-9 were found to be free of stenosis on CTCA. On a CCS of 10-99, 110 out of 121 (91%) patients were either free of stenosis or had mild stenosis. About 66 out of 79 (84%) patients had moderate or severe stenosis with a calcium score of 100-400 while none of the patients were free of stenosis. Around 28 out of 38 (74%) patients with a CCS of more than 400 had severe stenosis. However, only 04 patients (11%) were found to have mild stenosis. Spearman's rho revealed a correlation coefficient of 0.791 with a p-value of <0.001.
Our study reaffirms that in South Asian population, low CCS (<100) is associated with no or minimal stenosis while high CCS warrants further investigation; hence, making it a reliable tool for screening patients with CAD.
拥有像冠状动脉钙化评分（CCS）和CT冠状动脉造影（CTCA）这样用于冠状动脉疾病（CAD）的可行筛查工具的需求变得至关重要。我们旨在评估在南亚人群中，与CTCA所确定的相比，CCS在确定冠状动脉血管狭窄程度方面的准确性。
在阿迦汗大学医院进行了一项回顾性研究。共回顾了2008年至2010年间接受CCS和CTCA检查的539例患者记录。通过比较他们的CCS和CTCA结果来回顾患者记录。
在301例CCS为0 - 9的患者中，约268例（89%）在CTCA检查中未发现狭窄。CCS为10 - 99时，121例患者中有110例（91%）要么无狭窄要么有轻度狭窄。钙评分为100 - 400的79例患者中约66例（84%）有中度或重度狭窄，且无一例无狭窄。CCS大于400的38例患者中约28例（74%）有重度狭窄。然而，仅4例患者（11%）被发现有轻度狭窄。Spearman秩相关系数显示为0.791，p值<0.001。
我们的研究再次证实，在南亚人群中，低CCS（<100）与无狭窄或轻度狭窄相关，而高CCS则需要进一步调查；因此，使其成为筛查CAD患者的可靠工具。
