University of Connecticut School of Medicine, Farmington, Connecticut.
J Stroke Cerebrovasc Dis. 2013 Nov;22(8):e541-5. doi: 10.1016/j.jstrokecerebrovasdis.2013.06.015. Epub 2013 Jul 16.
Intracerebral hemorrhage (ICH) is a severe type of stroke for which there is currently no specific medical therapy. We hypothesized that statins reduce immediate inflammatory injury and improve long-term recovery from increased neurogenesis and angiogenesis. We conducted a large retrospective cohort study to assess the influence of statin therapy on patient death and disability at 12 months after ICH.
This was a retrospective analysis of a prospectively collected database at a tertiary care medical center. Patients were grouped based on statin use, and poor outcome was assessed as dead or alive with dependency (modified Barthel Index≤14).
We compared outcomes in 190 patients exposed to statins to 236 patients who were not exposed to statins. Univariate analysis found that statin use was associated with decreased mortality in-hospital and at 12 months (P=.001). Multivariable analysis found that statin use was associated with a decreased odds of death or disability at 12 months after ICH (odds ratio 0.44; 95% confidence interval 0.21-0.95).
Statin use is associated with improved long-term outcome at 12 months after ICH. This finding supports previous clinical studies that have shown the short-term benefits of statin therapy. In addition, this study correlates with animal studies supporting the possible long-term recovery benefits of statins.
脑出血（ICH）是一种严重的中风类型，目前尚无特定的医学治疗方法。我们假设他汀类药物可以减轻炎症损伤，并通过增加神经发生和血管生成来改善长期的恢复。我们进行了一项大型回顾性队列研究，以评估他汀类药物治疗对 ICH 后 12 个月患者死亡和残疾的影响。
这是对三级医疗中心前瞻性收集数据库的回顾性分析。根据他汀类药物的使用情况将患者分组，不良预后评估为死亡或依赖（改良巴氏指数≤14）的存活。
我们比较了 190 名接受他汀类药物治疗的患者和 236 名未接受他汀类药物治疗的患者的结局。单因素分析发现，他汀类药物的使用与住院期间和 12 个月时死亡率降低有关（P=0.001）。多变量分析发现，他汀类药物的使用与 ICH 后 12 个月死亡或残疾的几率降低相关（比值比 0.44；95%置信区间 0.21-0.95）。
他汀类药物的使用与 ICH 后 12 个月的长期预后改善相关。这一发现支持了先前表明他汀类药物治疗短期获益的临床研究。此外，这项研究与支持他汀类药物可能具有长期恢复益处的动物研究相关。
