口服苯丙氨酸对Wistar大鼠中由N-甲基-N'-硝基-N-亚硝基胍诱导的胃癌发生的保护作用。
Protection by oral phenylalanine against gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats.
作者信息
Iishi H, Tatsuta M, Baba M, Okuda S, Taniguchi H
机构信息
Department of Gastrointestinal Oncology, Center for Adult Diseases, Osaka, Japan.
出版信息
Br J Cancer. 1990 Aug;62(2):173-6. doi: 10.1038/bjc.1990.255.
The effect of oral administration of L-phenylalanine on the incidence and histology of gastric adenocarcinomas induced by N-methyl-N'-nitro-N-nitrosoguanidine was investigated in inbred Wistar rats. Oral administration of 6% phenylalanine after 25 weeks of treatment with the carcinogen significantly reduced the incidence and number of adenocarcinomas of the glandular stomach at experimental week 52. Oral administration of high dose phenylalanine significantly increased the basal serum gastrin level and significantly decreased the norepinephrine concentration in the antral portion of the gastric wall, as well as the labelling indices of antral mucosa. These findings indicate that orally administered phenylalanine inhibits the development of gastric cancers.
在近交系Wistar大鼠中，研究了口服L-苯丙氨酸对N-甲基-N'-硝基-N-亚硝基胍诱导的胃腺癌发病率和组织学的影响。在用致癌物处理25周后口服6%苯丙氨酸，在实验第52周时显著降低了腺胃腺癌的发病率和数量。口服高剂量苯丙氨酸显著提高了基础血清胃泌素水平，并显著降低了胃壁窦部的去甲肾上腺素浓度以及窦部黏膜的标记指数。这些发现表明，口服苯丙氨酸可抑制胃癌的发展。
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