Vorobjev Y N
Institute of Bioorganic Chemistry, Siberian Division, USSR Academy of Sciences, Novosibirsk.
Biopolymers. 1990 Oct-Nov;29(12-13):1519-29. doi: 10.1002/bip.360291203.
The two-level hierarchical methodology is suggested for conformational calculations of large fragments of nucleic acids. The method of the first level is intended for performing a fast screening of the conformational phase space. The high-level method may be used to refine structurally important conformations. The method of the first level is the block-units method, which has been developed specially for these purposes (see part I). It has been shown that the block-units method allows the satisfactory calculation of the structure parameters of the optimal conformations of polynucleotides. The results of the conformational rearrangement calculations of the T psi C loop of the tRNA(Phe) after modification of its sequence are represented.
对于核酸大片段的构象计算，建议采用两级分层方法。第一级方法旨在对构象相空间进行快速筛选。高级方法可用于优化结构上重要的构象。第一级方法是块单元法，它是专门为这些目的而开发的（见第一部分）。已经表明，块单元法能够令人满意地计算多核苷酸最佳构象的结构参数。展示了tRNA（Phe）的T psi C环序列修饰后构象重排计算的结果。
