Neuroimmunology and Multiple Sclerosis Research Section, Department of Neurology, University Hospital Zurich, Zurich; Department of Neurology, University Hospital Zurich, Zurich.
Ann Neurol. 2013 Oct;74(4):622-6. doi: 10.1002/ana.23973. Epub 2013 Sep 16.
Progressive multifocal leukoencephalopathy is the most common clinical presentation of JC virus (JCV)-associated central nervous system (CNS) disease and has emerged as a major safety concern in multiple sclerosis patients treated with the monoclonal antibody natalizumab. Here we report clinical, radiological, and histological findings of a case of cerebellar granule cell neuronopathy (GCN), a JCV-associated CNS disease, so far unreported amongst patients treated with natalizumab. GCN should be considered as a JCV CNS manifestation in patients with newly developed, progressive cerebellar signs under natalizumab treatment, especially in cases where cerebellar atrophy can be visualized by magnetic resonance imaging.
进行性多灶性白质脑病是 JCV（JC 病毒）相关中枢神经系统 (CNS) 疾病最常见的临床表现，并且在接受单克隆抗体那他珠单抗治疗的多发性硬化症患者中已成为一个主要的安全隐患。在此，我们报告了一例小脑颗粒细胞神经元病（GCN）的病例，这是一种与 JCV 相关的 CNS 疾病，迄今为止，在接受那他珠单抗治疗的患者中尚未报道过。在接受那他珠单抗治疗的患者中，如果出现新的、进行性小脑体征，特别是可以通过磁共振成像观察到小脑萎缩的情况下，应考虑 GCN 是 JCV CNS 表现。
