Kaya Z, Kaya B C, Sezen H, Bilinc H, Asoglu R, Yildiz A, Taskin A, Yalcin S, Sezen Y, Aksoy N
Department of Cardiology, Harran University, Sanlıurfa, Turkey.
Clin Ter. 2013 May-Jun;164(3):e187-91. doi: 10.7417/CT.2013.1558.
Ceruloplasmin (Cp) is a serum protein that belongs to the family of α2-globulins and it is increased in patients with after acute myocardial infarction complicated with heart failure. Aim of the study was to investigate levels of serum Cp in patients with acute decompensated heart failure.
The present cross-sectional observational study consists of three groups: Fifty patients with decompensated heart failure (Group 1) and same 50 patients after compensation (Group 2); 50 control patients group with comparable age and sex without heart failure (Group 3). Demographic, echocardiographic and biochemical data of patients were collected. Serum Cp level was determined spectrophotometrically.
Serum ceruloplasmin was significantly increased in Groups 1 (820.8 ± 78.5 IU/dL) and 2 (873.5 ± 121.0 IU/dL) compared, to Group 3 (640.6 ± 132.4 IU/dL) (p<0.001). In the sub-group analysis, this difference was due to the difference between Groups 3, Group 1 and 2 (both p=0.0001) whereas no significant difference was present between Group I and Group 2 (p>0.063). A positive correlation was found between Cp and female sex, heart rate, systolic and diastolic blood pressure, acetylsalisilic acid and diuretic use, left ventricular systolic and diastolic diameter, mitral regurgitation, and negative correlation was found between Cp and ejection fraction (p<0.05 for all) whereas none of the parameters were independently associated with serum Cp level (p>0.05).
Findings of the present study suggest that serum Cp level is increased in both decompensated and compensated HF compared to controls. Further large scale studies are needed to elucidate the pathophysiological mechanisms of increased Cp in HF.
铜蓝蛋白（Cp）是一种属于α2球蛋白家族的血清蛋白，在急性心肌梗死合并心力衰竭患者中升高。本研究旨在调查急性失代偿性心力衰竭患者的血清Cp水平。
本横断面观察性研究包括三组：50例失代偿性心力衰竭患者（第1组）和50例病情缓解后的同一批患者（第2组）；50例年龄和性别匹配的无心力衰竭对照患者（第3组）。收集患者的人口统计学、超声心动图和生化数据。采用分光光度法测定血清Cp水平。
与第3组（640.6±132.4 IU/dL）相比，第1组（820.8±78.5 IU/dL）和第2组（873.5±121.0 IU/dL）的血清铜蓝蛋白显著升高（p<0.001）。亚组分析显示，这种差异是由于第3组与第1组和第2组之间的差异所致（p均=0.0001），而第1组和第2组之间无显著差异（p>0.063）。发现Cp与女性、心率、收缩压和舒张压、乙酰水杨酸和利尿剂使用、左心室收缩和舒张直径、二尖瓣反流呈正相关，与射血分数呈负相关（所有p<0.05），而这些参数均与血清Cp水平无独立相关性（p>0.05）。
本研究结果表明，与对照组相比，失代偿性和代偿性心力衰竭患者的血清Cp水平均升高。需要进一步开展大规模研究以阐明心力衰竭中Cp升高的病理生理机制。
