Slotman B J, Nauta J J, Rao B R
Department of Endocrinology, Academisch Ziekenhuis Vrije Universiteit, Amsterdam, The Netherlands.
Cancer. 1990 Aug 15;66(4):740-4. doi: 10.1002/1097-0142(19900815)66:4<740::aid-cncr2820660423>3.0.co;2-h.
Estrogen (ER), progesterone (PR), and androgen receptors (AR) were determined by saturation analysis in 100 cases of primary ovarian cancer and correlated with patient survival. The mean follow-up period was 5.4 years (range, 4 to 6.5 years). Positivity for PR was associated with a significantly better survival rate (P less than 0.05). A similar observation was made for AR (P less than 0.05). Tumor ER content did not correlate with survival. Ten patients with tumors that had negative results for both PR and AR all died of the disease. In 91 cases of serous, endometrioid, and mucinous carcinomas, grade, stage, and tumor PR content, but not AR content, were identified as independent prognostic factors with the use of the Cox proportional hazards model. The relative risk of patients with PR-negative tumors was 2.3 times higher than that of patients with tumors containing high (greater than or equal to 30 fmol/mg) PR levels.
通过饱和分析测定了100例原发性卵巢癌患者的雌激素（ER）、孕激素（PR）和雄激素受体（AR），并将其与患者生存率进行了关联分析。平均随访期为5.4年（范围4至6.5年）。PR阳性与显著更好的生存率相关（P<0.05）。AR也有类似观察结果（P<0.05）。肿瘤ER含量与生存率无关。10例PR和AR均为阴性的肿瘤患者均死于该疾病。在91例浆液性、子宫内膜样和黏液性癌中，使用Cox比例风险模型确定，肿瘤分级、分期和PR含量而非AR含量为独立的预后因素。PR阴性肿瘤患者的相对风险比PR水平高（≥30 fmol/mg）的肿瘤患者高2.3倍。
