Athanassiadou P, Sakellariou V, Petrakakou E, Athanassiades P, Zerva C, Liossi A, Michalas S
Athens University, Pathology Laboratory, Department of Cytology, Athen, Greece.
Pathol Oncol Res. 1998;4(2):103-7. doi: 10.1007/BF02904702.
In view of the somewhat inconclusive nature of the reports of the role of Cathepsin D (Cath D) in ovarian carcinoma and its relationship with various other parameters of malignancy the present study was performed to aid in the further clarification of this role. One hundred freshly resected primary ovarian carcinomas of various histological types were studied for ER, PR and Cath D status and the results examined with respect to menopausal status, histology, size and lymph node invasion. In our series Cath D positivity was more frequent in serous than in other types of ovarian cancer but this Cath D positivity was not related to the frequency of lymph node invasion regardless of the size of the tumor. Nor was any association observed between Cath D positivity and ER or PR status of the tumors or the menopausal state of the patients. The reported prognostic value of Cath D, ER and PR is discussed as well as the distinction between tumor invasion by lymphatic channels and direct interstitial infiltration. It was concluded that Cath D may not play a role in the former mode but, as might be expected from its proteolytic properties, in local spread by means of tissue destruction.
鉴于组织蛋白酶D（Cath D）在卵巢癌中的作用及其与其他各种恶性参数的关系的报道有些不确定，进行了本研究以帮助进一步阐明这一作用。对100例新鲜切除的各种组织学类型的原发性卵巢癌进行了雌激素受体（ER）、孕激素受体（PR）和Cath D状态的研究，并根据绝经状态、组织学、大小和淋巴结浸润情况对结果进行了检查。在我们的系列研究中，浆液性卵巢癌中Cath D阳性比其他类型的卵巢癌更常见，但这种Cath D阳性与淋巴结浸润频率无关，无论肿瘤大小如何。在肿瘤的Cath D阳性与ER或PR状态或患者的绝经状态之间也未观察到任何关联。讨论了所报道的Cath D、ER和PR的预后价值以及淋巴管侵袭与直接间质浸润之间的区别。得出的结论是，Cath D可能在前一种模式中不起作用，但正如从其蛋白水解特性所预期的那样，在通过组织破坏进行的局部扩散中起作用。
