Epelman S, Estrada J, Jaffe N, Bianchi A
A.C. Camargo Hospital, Department of Pediatrics, Sao Paulo, Brazil.
Cancer. 1990 Aug 15;66(4):801-5. doi: 10.1002/1097-0142(19900815)66:4<801::aid-cncr2820660434>3.0.co;2-b.
Six patients with extremity osteosarcoma initially underwent successful treatment of the primary tumor with four to seven courses of intraarterial cis-diamminedichloroplatin-II (IA-CDP; 100 to 150 mg/m2/course). The primary tumors in two patients were then extirpated by limb salvage. However, a local soft tissue recurrence occurred in both patients several months later. The other four patients refused surgical intervention and later also developed local bony recurrences. Reinstatement of three to five courses of IA-CDP in all six patients induced a complete response in five. The local recurrences (bony and soft tissue) in all six patients were excised. This included limb-salvage procedures in three patients. Additional postoperative chemotherapy was administered. Four patients remain alive and continuously free of disease 3.5+ to 4.5+ years after retreatment with IA-CDP.
6例肢体骨肉瘤患者最初接受了4至7个疗程的动脉内顺二氯二氨铂-II（IA-CDP；100至150mg/m²/疗程）治疗，原发肿瘤获得成功治疗。随后，2例患者的原发肿瘤通过保肢手术切除。然而，数月后这2例患者均出现局部软组织复发。另外4例患者拒绝手术干预，随后也出现了局部骨复发。所有6例患者再次接受3至5个疗程的IA-CDP治疗，5例获得完全缓解。所有6例患者的局部复发（骨和软组织）均被切除，其中3例患者接受了保肢手术。术后给予辅助化疗。4例患者在接受IA-CDP再治疗后3.5年至4.5年以上仍存活且持续无病。
