St Peter's Andrology Centre, UCL, London, UK.
Int J Clin Pract. 2013 Aug;67(8):781-8. doi: 10.1111/ijcp.12129.
To correct common misconceptions about Peyronie's disease (PD) that present obstacles to early recognition and treatment.
The prevalence, natural disease course, psychosocial effects and treatment considerations for patients with PD were reviewed.
Studies over the past decade have shown that the prevalence of PD may be higher (up to 20%) than previously thought. PD can lead to emotional and relationship distress. Nearly 10% of men who present with PD are younger than 40. Both younger age and comorbid vascular disease have been associated with more severe and progressive PD. In the majority of patients, symptoms will either deteriorate or remain stable. PD is often associated with erectile dysfunction (ED). Effective, minimally invasive treatments used early in the disease course include unapproved and/or investigational intralesional injection therapy with verapamil, interferon (IFN) α-2b, or collagenase clostridium histolyticum (CCH). Surgical intervention is considered in patients with ED and/or penile deformity that impairs sexual functioning; however, preoperative discussion of appropriate expectations is important.
The availability of effective minimally invasive and surgical therapies for PD suggests that active management should be considered over a 'wait-and-see' approach.
Providing early intervention and improved education/awareness of PD as a chronic and progressive disorder may result in improved physical and psychosocial outcomes for PD patients. As general practitioners are often the first contact for men with PD, they are well positioned to recognise symptoms early and promptly refer patients for further evaluation and treatment.
纠正人们对 Peyronie 病（PD）的常见误解，这些误解会阻碍早期识别和治疗。
回顾了 PD 患者的患病率、自然病程、心理社会影响和治疗注意事项。
过去十年的研究表明，PD 的患病率可能高于以往认为的水平（高达 20%）。PD 可导致情绪和人际关系困扰。近 10%的 PD 患者年龄小于 40 岁。年龄较小和合并血管疾病与更严重和进行性 PD 相关。在大多数患者中，症状要么恶化，要么保持稳定。PD 常伴有勃起功能障碍（ED）。在疾病早期，有效、微创的治疗方法包括未经批准和/或研究性腔内注射维拉帕米、干扰素（IFN）α-2b 或胶原酶溶组织梭菌（CCH）治疗。对于 ED 和/或影响性功能的阴茎畸形患者，考虑手术干预；然而，术前讨论适当的预期很重要。
PD 有有效的微创和手术治疗方法，这表明应考虑积极治疗而非“观望”。
对 PD 作为一种慢性和进行性疾病进行早期干预和改善教育/意识，可能会改善 PD 患者的身体和心理社会结局。由于全科医生通常是 PD 患者的第一接触者，他们能够及早识别症状，并及时转介患者进行进一步评估和治疗。
