Yamashita Hiromi, Zeredo Jorge L, Kaida Kei, Kimoto Mari, Asahina Izumi, Toda Kazuo
Oral Surgery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8588, Japan.
J Integr Neurosci. 2013 Jun;12(2):235-46. doi: 10.1142/S0219635213500143. Epub 2013 Jun 24.
In the limbic system, the anterior cingulate cortex (ACCX) is one of the key areas involved in the close association between pain and emotion. However, neuronal changes in ACCX nociceptive responses after stress conditioning have not yet been quantitatively investigated. We investigated the modulation of nociceptive responses in the ACCX neurons following restraint stress in rats. The present study demonstrated that stress-conditioning enhanced excitatory nociceptive responses in the ACCX following tail stimuli in the mid-term (7 days). Short-term (3 days) and long-term (21 days) of stress conditioning did not affect these responses significantly. Nociceptive responses evoked by other sites of the body (nose, back and four paws) stimulation were not changed by stress-conditioning, indicating that neural information from the tail is important for emotional system modulation. It is suggested that the emotional/affective part of the pain sensation is strongly modified by stress through neuroplasticity in the ACCX.
在边缘系统中，前扣带回皮质（ACCX）是参与疼痛与情绪紧密关联的关键区域之一。然而，应激条件作用后ACCX伤害性反应中的神经元变化尚未得到定量研究。我们研究了大鼠束缚应激后ACCX神经元伤害性反应的调节情况。本研究表明，应激条件作用在中期（7天）增强了ACCX对尾部刺激的兴奋性伤害性反应。短期（3天）和长期（21天）的应激条件作用对这些反应没有显著影响。身体其他部位（鼻子、背部和四肢）刺激所诱发的伤害性反应并未因应激条件作用而改变，这表明来自尾部的神经信息对于情绪系统调节很重要。研究表明，疼痛感觉的情绪/情感部分通过ACCX中的神经可塑性被应激强烈改变。
