Boekstegers P, Diebold J, Weiss C
Department of Physiology, Medical University of Lübeck, West Germany.
Cardiovasc Res. 1990 Jun;24(6):456-64. doi: 10.1093/cvr/24.6.456.
The aim of the study was to test an intermittent ECG synchronised suction device which was added to a coronary vein retroinfusion system (selective suction and retroinfusion = SSR) in order to transport oxygenated fluid more efficiently into ischaemic myocardium.
The suction period preceding the retrograde pumping period was sufficient to allow the coronary veins to empty upstream of the retroinfusion catheter tip, thus facilitating the refilling of the veins by the retrogradely pumped oxygenated fluid. Subepicardial oxygen partial pressure measurements and determination of post mortem infarct size were used to study the efficacy of SSR treatment in an open chest infarct model.
15 beagle dogs were subjected to occlusion of the left anterior descending coronary artery for up to 5 h.
Using oxygenated Ringer lactate solution for SSR treatment (given 30 min to 5 h after occlusion of the left anterior descending artery), mean subepicardial PO2 in the ischaemic myocardium of SSR treated dogs increased by 7-12 mm Hg. Mean infarct size was reduced to 5.6(SD 3)% of left ventricle in SSR treated dogs (n = 4) compared to 27(14)% in controls (n = 4). Expressed as percent of volume at risk, mean infarct size was reduced by 84% in SSR treated dogs.
These data suggest that intermittent suction increased the efficacy of coronary venous retroinfusion in acute myocardial ischaemia.
本研究旨在测试一种间歇性心电图同步吸引装置，该装置被添加到冠状动脉逆行灌注系统（选择性吸引和逆行灌注=SSR）中，以便更有效地将含氧液体输送到缺血心肌中。
逆行泵送期之前的吸引期足以使冠状静脉在逆行灌注导管尖端上游排空，从而便于通过逆行泵送的含氧液体使静脉重新充盈。在开胸梗死模型中，使用心外膜下氧分压测量和死后梗死面积测定来研究SSR治疗的效果。
15只比格犬接受左冠状动脉前降支闭塞长达5小时。
使用含氧乳酸林格液进行SSR治疗（在左冠状动脉前降支闭塞后30分钟至5小时给予），接受SSR治疗的犬缺血心肌中心外膜下平均PO2升高7-12mmHg。与对照组（n=4）的27（14）%相比，接受SSR治疗的犬（n=4）的平均梗死面积减少至左心室的5.6（标准差3）%。以危险体积的百分比表示，接受SSR治疗的犬的平均梗死面积减少了8
