Institute of Molecular Health Sciences, Swiss Federal Institute of Technology, ETH Zürich, Schafmattstrasse 22, 8049 Zurich, Switzerland.
Mol Cell. 2013 Jul 25;51(2):131-2. doi: 10.1016/j.molcel.2013.07.007.
Spreading of dosage compensation over the X chromosome in Drosophila males requires the noncoding roX1 and roX2 RNAs. In this issue, Ilik et al. (2013) and Maenner et al. (2013) show that these RNAs contain discrete binding sites that are remodeled during assembly of the dosage compensation complex.
在果蝇雄性中,X 染色体上的剂量补偿需要非编码的 roX1 和 roX2 RNA。在本期中,Ilik 等人(2013)和 Maenner 等人(2013)表明,这些 RNA 包含离散的结合位点,这些结合位点在剂量补偿复合物组装过程中被重塑。