Applied Organic Chemistry Department, National Research Centre, Cairo, Egypt.
Eur J Med Chem. 2013 Sep;67:263-8. doi: 10.1016/j.ejmech.2013.06.031. Epub 2013 Jun 21.
New series of thiosemicarbazone derivatives incorporating a hippuric acid moiety have been synthesized through the reaction of N-(4-hippuric acid)thiosemicarbazide with various carbonyl compounds such as aldehydes, ketones and cyclic ketones. The synthesized compounds were tested against bacterial and fungal strains. Most of compounds, such as 2-(4-(2-(4-fluorobenzylidene)hydrazinecarbothioamido)benzamido)acetic acid showed significant antibacterial and antifungal activities. These compounds comprise a new class of promising broad-spectrum antibacterial and antifungal agents.
新系列的缩氨基硫脲衍生物结合了一个马尿酸部分，通过 N-(4-马尿酸)缩氨基硫脲与各种羰基化合物如醛、酮和环酮的反应合成。合成的化合物被测试了对细菌和真菌菌株的活性。大多数化合物，如 2-(4-(2-(4-氟亚苄基)腙基硫代酰胺基)苯甲酰胺基)乙酸表现出显著的抗菌和抗真菌活性。这些化合物构成了一类有前途的广谱抗菌和抗真菌药物。
