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钯催化硼酸对炔醇醚的加成反应：三取代乙烯基醚的高区域和立体选择性合成。

Pd-catalyzed addition of boronic acids to ynol ethers: a highly regio- and stereoselective synthesis of trisubstituted vinyl ethers.

机构信息

Department of Chemistry, Zhejiang Normal University, 688 Yingbin Road, Jinhua 321004, China.

出版信息

Chem Commun (Camb). 2013 Sep 7;49(69):7650-2. doi: 10.1039/c3cc43793k. Epub 2013 Jul 22.

DOI:10.1039/c3cc43793k
PMID:23873049
Abstract

A Pd-catalyzed addition of boronic acids to ynol ethers has been realized, delivering trisubstituted vinyl ethers in good yields with perfect control of the regio- and stereoselectivity. The reaction proceeds under mild conditions and exhibits excellent functional group compatibility. Moreover, the resultant products can be converted into pentasubstituted benzenes via the tandem Diels-Alder/aromatization reaction.

摘要

钯催化硼酸与炔醇醚的加成反应已经实现，以优异的区域和立体选择性得到了高产率的三取代乙烯基醚。该反应在温和的条件下进行，具有极好的官能团兼容性。此外，所得产物可以通过串联的 Diels-Alder/芳构化反应转化为五取代苯。

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