Department of Radiation Oncology, University Hospital Heidelberg, Germany.
Z Med Phys. 2013 Dec;23(4):324-31. doi: 10.1016/j.zemedi.2013.06.006. Epub 2013 Jul 20.
Whenever treating a patient with percutaneous radiotherapy, a certain amount of dose is inevitably delivered to healthy tissue. This is mainly due to beam's entry and exit in the region of the target volume. In regions distant from the target volume, dose is delivered by leakage from the MLC and head scatter from the accelerator head and phantom scatter from the target volume (peripheral dose). Helical tomotherapy is a form of radiation therapy with a uniquely designed machine and delivery pattern which influence the peripheral dose. The goal of this work was to investigate peripheral dose in helical tomotherapy. The experiments were used to establish a complex characterization of the peripheral dose.
A 303060cm(3) slab phantom and TLD-100 (Lithium fluoride) were used for the experiments. Treatment procedures were generated with the tomotherapy planning system (TPS). Additionally, procedures were created on the Operator Station of the tomotherapy system without a calculation of the dose distribution. The peripheral dose which was produced by a typical tomotherapy treatment plan was measured. Furthermore, these procedures were used to differentiate the parts of the peripheral dose in phantom scatter dose and head scatter and leakage dose. Additionally, the relation between peripheral dose and treatment time and between peripheral dose and delivered dose was investigated. Additionally, the peripheral dose was measured in an Alderson phantom.
Distances of 30cm or more resulted in a decrease of the peripheral dose to less than 0.1% of the target dose. The measured doses have an offset of approximately 1cGy in comparison to the calculated doses from the TPS. The separated head scatter and leakage dose was measured in the range of 1cGy for typical treatments. Furthermore, the investigations show a linear correlation between head scatter leakage dose and treatment time and between scatter dose parts and delivered dose. A peripheral dose of 0.28% of the target dose was measured in the Alderson phantom at a distance of 17.5cm from the edge of the target volume.
The peripheral dose delivered by a tomotherapy treatment is clinically unobjectionable. The measurements confirmed a linear correlation between head scatter and leakage and treatment time and between scatter dose and delivered dose.
在对患者进行经皮放射治疗时,不可避免地会对健康组织给予一定剂量。这主要是由于射束在靶区的进入和离开。在远离靶区的区域,剂量通过从多叶准直器泄漏、从加速器机头散射和从靶区散射(周边剂量)传递。螺旋断层放疗是一种具有独特设计的机器和传递模式的放射治疗形式,这会影响周边剂量。本工作的目的是研究螺旋断层放疗中的周边剂量。该实验用于建立周边剂量的复杂特征描述。
使用 303060cm(3)平板模体和 TLD-100(氟化锂)进行实验。在断层放疗计划系统(TPS)上生成治疗程序。此外,在断层放疗系统的操作员站创建程序,而不计算剂量分布。测量典型断层放疗计划产生的周边剂量。此外,这些程序用于区分模体散射剂量、机头散射和泄漏剂量中的周边剂量部分。此外,还研究了周边剂量与治疗时间之间的关系,以及周边剂量与递送剂量之间的关系。此外,在 Alderson 模体中测量了周边剂量。
距离 30cm 或更大距离会使周边剂量降低到靶剂量的 0.1%以下。与 TPS 计算的剂量相比,测量的剂量有大约 1cGy 的偏移。对于典型治疗,测量的头散射和泄漏剂量分离部分在 1cGy 范围内。此外,研究表明,头散射泄漏剂量与治疗时间之间以及散射剂量部分与递送剂量之间存在线性相关性。在距离靶区边缘 17.5cm 的 Alderson 模体中测量到 0.28%的靶剂量的周边剂量。
断层放疗治疗中传递的周边剂量在临床上是可以接受的。测量结果证实了头散射和泄漏与治疗时间之间以及散射剂量与递送剂量之间的线性相关性。