Franceschi C, Cossarizza A, Troiano L, Salati R, Monti D
Institute of General Pathology, University of Modena, Italy.
Int J Clin Pharmacol Res. 1990;10(1-2):53-7.
Several immune parameters--particularly T-cell dependent immune responses--are altered in aged subjects. To test the hypothesis that they may be the consequence of more general age-related lymphocyte biochemical alterations, and particularly of the energy producing system, the effect of L-carnitine and acetyl-L-carnitine on cell proliferation was studied in peripheral blood lymphocytes from donors of different ages. The results showed that phytohaemagglutinin-induced peripheral blood lymphocyte proliferation was markedly increased in L-carnitine- or acetyl-L-carnitine-preloaded lymphocytes from young and especially from old subjects. Cells from aged subjects considerably improved their defective proliferative capability. Preliminary observations suggest that L-carnitine-preloading also protected peripheral blood lymphocytes from old donors when such cells were exposed to an oxidative stress.
在老年受试者中，多项免疫参数——尤其是T细胞依赖性免疫反应——会发生改变。为了验证它们可能是更普遍的与年龄相关的淋巴细胞生化改变的结果，特别是能量产生系统改变的结果这一假设，研究了左旋肉碱和乙酰左旋肉碱对不同年龄供体外周血淋巴细胞增殖的影响。结果表明，在预先加载左旋肉碱或乙酰左旋肉碱的年轻受试者尤其是老年受试者的外周血淋巴细胞中，植物血凝素诱导的外周血淋巴细胞增殖显著增加。老年受试者的细胞显著改善了其有缺陷的增殖能力。初步观察表明，当老年供体的外周血淋巴细胞暴露于氧化应激时，预先加载左旋肉碱也能保护这些细胞。
