Morrison J C, Cork L C, Dunkelberger G R, Brown A, Quigley H A
Oregon Health Sciences University, Portland.
Invest Ophthalmol Vis Sci. 1990 Aug;31(8):1623-7.
The authors counted axons in one optic nerve from each of 28 juvenile and aged rhesus monkeys using an automated image analysis system. All nerves were fixed immediately after death and treated identically. Animals ranged in age from 1 1/2 to 29 yr, which correlates with a human age range of 4 1/2-87 yr. Mean axonal number for all specimens was 1,117,859. Large variations in axonal numbers were found, even within a subgroup of ten animals aged 1 1/2-2 yr. Although young nerves had generally more fibers than those from old animals, this difference was not quite statistically significant, translating into a yearly loss of 4319 fibers (0.45% of the total). Age did not have any significant effect on mean axonal diameter.
作者使用自动图像分析系统对28只幼年和成年恒河猴的每只视神经中的轴突进行了计数。所有神经在死后立即固定，并进行相同处理。动物年龄范围为1.5至29岁，这与人类4.5至87岁的年龄范围相关。所有标本的平均轴突数量为1,117,859。即使在1.5至2岁的十只动物亚组中，也发现轴突数量存在很大差异。虽然年轻神经的纤维通常比老年动物的多，但这种差异在统计学上并不十分显著，相当于每年损失4319根纤维（占总数的0.45%）。年龄对平均轴突直径没有任何显著影响。
