Lairet Kimberly F, Baer David, Leas Michelle L, Renz Evan M, Cancio Leopoldo C
From the U.S. Army Institute of Surgical Research, Fort Sam Houston, Texas.
J Burn Care Res. 2014 May-Jun;35(3):214-8. doi: 10.1097/BCR.0b013e31829b3338.
Accelerating the healing process and reducing pain during healing are beneficial for the following reasons: faster return to work, lower risk of wound infection, improved quality of life, and possibly reduced need for analgesia. This clinical study assessed the effectiveness of a new oxygen-diffusion dressing (OxyBand; Oxyband Technologies, St. Louis, MO) compared with standard Xeroform gauze dressings (Convidien, Mansfield, MA), in the care of skin-graft donor sites in burn patients. Time to healing was the primary endpoint, and pain scores and cosmetic outcome were also assessed. This was a prospective, randomized, controlled study of burn patients undergoing harvesting of two donor sites. Patients were followed at predetermined time points for 30 to 45 days to determine the time to reepithelialization, cosmetic appearance, and pain. Subjects were adult burn patients with less than 30% TBSA burns admitted to the burn center, who required excision and grafting. Twenty patients were enrolled, of whom 17 completed the study. Average age was 35 years. Average burn size was 9.2% TBSA. Patients underwent harvesting of split-thickness skin grafts with one donor wound dressed with OxyBand and the other dressed in Xeroform gauze. Wounds were inspected and photographed on postoperative days 4 and 8, and then every 2 days until the donor wounds were healed. Pain scores at each site were also collected at these visits (rated by patients on a scale from 0 to 10). Mean time to wound healing for OxyBand was 9.3 ± 1.7 days; for Xeroform, 12.4 ± 2.7 days (P < .001). Pain scores were lower (P < .01) at the OxyBand site compared with the Xeroform site at all time points during postoperative days 4 to 12. There was no difference in the cosmetic outcome of the wounds at 30 to 45 days postoperatively. This study revealed a decrease in the time to healing and in pain at donor sites dressed with an oxygen-diffusion dressing.
更快重返工作岗位、降低伤口感染风险、提高生活质量，且可能减少镇痛需求。本临床研究评估了一种新型氧扩散敷料（OxyBand；Oxyband Technologies，密苏里州圣路易斯市）与标准的干纱布敷料（康维德公司，马萨诸塞州曼斯菲尔德市）相比，在烧伤患者皮肤移植供区护理中的有效性。愈合时间是主要终点，同时还评估了疼痛评分和美容效果。这是一项对接受两个供区取皮手术的烧伤患者进行的前瞻性、随机对照研究。在预定时间点对患者进行30至45天的随访，以确定上皮化时间、外观和疼痛情况。受试者为入住烧伤中心、烧伤总面积小于30%TBSA且需要进行切除和植皮的成年烧伤患者。招募了20名患者，其中17名完成了研究。平均年龄为35岁。平均烧伤面积为9.2%TBSA。患者接受了中厚皮片移植，一个供区伤口用OxyBand敷料包扎，另一个用干纱布敷料包扎。术后第4天和第8天对伤口进行检查和拍照，然后每2天检查一次，直至供区伤口愈合。在每次访视时还收集每个部位的疼痛评分（由患者按0至10分进行评分）。OxyBand组伤口愈合的平均时间为9.3±1.7天；干纱布组为12.4±2.7天（P<.001）。在术后第4至12天的所有时间点，OxyBand组的疼痛评分均低于干纱布组（P<.01）。术后30至45天，伤口的美容效果没有差异。本研究表明，使用氧扩散敷料包扎的供区伤口愈合时间缩短，疼痛减轻。
