Krysiak Robert, Kedzia Agnieszka, Krupej-Kedzierska Joanna, Okopień Bogusław
Klinika Chorób Wewnetrznych i Farmakologii Klinicznej Katedry Farmakologii, Slaski Uniwersytet Medyczny, Katowice.
Przegl Lek. 2013;70(2):76-80.
HIV infection is associated with a number of adverse consequences, including endocrine disorders. The endocrine changes associated with HIV infection have been studied in depth and, as the results of so far carried out studies suggest, their aetiology is usually multifactoral. Their pathogenesis includes direct infection of endocrine glands by HIV or opportunistic organisms, infiltration by neoplasms and adverse effects of drugs. Endocrine problems that most frequently affect this group of patients include: hypogonadism, adrenal insufficiency, thyroid disorders, impaired growth hormone release, lipodystrophy and bone loss. They may develop in both the early as well as late stages of the infection, ranging from subclinical disturbances to overt endocrine symptoms. The purpose of this paper is to review the aetiology, clinical manifestations, diagnosis and treatment of HIV-associated endocrine disturbances with a special emphasis on the most recent literature.
HIV感染与许多不良后果相关，包括内分泌紊乱。与HIV感染相关的内分泌变化已得到深入研究，而且，正如迄今为止所开展研究的结果表明，其病因通常是多因素的。其发病机制包括HIV或机会性生物体对内分泌腺的直接感染、肿瘤浸润以及药物的不良反应。最常影响这组患者的内分泌问题包括：性腺功能减退、肾上腺功能不全、甲状腺疾病、生长激素释放受损、脂肪代谢障碍和骨质流失。它们可能在感染的早期和晚期出现，范围从亚临床紊乱到明显的内分泌症状。本文的目的是回顾HIV相关内分泌紊乱的病因、临床表现、诊断和治疗，并特别强调最新文献。
