Department of Nephrology, Evangelismos General Hospital, Athens, Greece.
Ren Fail. 2013 Sep;35(8):1075-8. doi: 10.3109/0886022X.2013.815090. Epub 2013 Jul 23.
Calcification of coronary vessels progresses rapidly in hemodialysis (HD) patients and comprises a strong predictor of cardiovascular events. The aim of this prospective study was to evaluate the coronary artery calcification (CAC) in patients with end stage renal disease undergoing regular HD and to determine the effect of renal transplantation (RT) in the progression of CAC, using the Agatston technique for calcium scoring. The study included 20 patients with end-stage renal disease undergoing a regular HD treatment (16 males, 4 females) 54.1 ± 9.5 years old who had just received a renal transplant and 16 more HD patients (11 males, 5 females) 54.4 ± 13.8 years old as control group. The baseline evaluation showed a very high prevalence of CAC in both groups, which was positively correlated with age (p < 0.001) and CRP (p = 0.03). The second (follow-up) evaluation showed a significant slower progression of calcification after RT. In both groups, high calcium score values in the follow-up evaluation had a strong positive correlation with baseline calcium score (p < 0.001).
血管钙化在血液透析（HD）患者中进展迅速，是心血管事件的强有力预测因子。本前瞻性研究的目的是使用 Agatston 钙评分法评估接受常规 HD 治疗的终末期肾病患者的冠状动脉钙化（CAC），并确定肾移植（RT）对 CAC 进展的影响。该研究纳入了 20 名刚接受肾移植的终末期肾病患者（16 名男性，4 名女性），年龄为 54.1±9.5 岁，以及 16 名作为对照组的 HD 患者（11 名男性，5 名女性），年龄为 54.4±13.8 岁。基线评估显示两组 CAC 的患病率均非常高，且与年龄呈正相关（p<0.001），与 CRP 呈正相关（p=0.03）。第二次（随访）评估显示 RT 后钙化的进展明显减慢。在两组中，随访评估时的高钙评分值与基线钙评分呈强正相关（p<0.001）。
