Department of Otolaryngology-Head and Neck Surgery, Cancer Research Institute, Research Institute for Medical Sciences, Chungnam National University School of Medicine, 640 Daesa-Dong, Chung-Gu, Daejeon, 301-721, South Korea.
Eur Arch Otorhinolaryngol. 2014 May;271(5):1235-9. doi: 10.1007/s00405-013-2638-2. Epub 2013 Jul 24.
Ultrasonography (US) is a useful diagnostic modality for evaluation of the size and features of thyroid nodules. Tumor size is a key indicator of the surgical extent of thyroid cancer. We evaluated the difference in tumor sizes measured by preoperative US and postoperative pathologic examination in papillary thyroid carcinoma (PTC). We reviewed the medical records of 172 consecutive patients, who underwent thyroidectomy for PTC treatment. We compared tumor size, as measured by preoperative US, with that in postoperative specimens. And we analyzed a number of factors potentially influencing the size measurement, including cancer size, calcification and coexisting thyroiditis. The mean size of the tumor measured by preoperative US was 11.4, and 10.2 mm by postoperative pathologic examination. The mean percentage difference (US-pathology/US) of tumor sizes measured by preoperative US and postoperative pathologic examination was 9.9 ± 19.3%, which was statistically significant (p < 0.001). When the effect of tumor size (≤10.0 vs. 10.1-20.0 vs. >20.0 mm) and the presence of calcification or coexisting thyroiditis on the tumor size discrepancy between the two measurements was analyzed, the mean percentage differences according to tumor size (9.1 vs. 11.2% vs. 9.8%, p = 0.842), calcification (9.2 vs. 10.2%, p = 0.756) and coexisting thyroiditis (17.6 vs. 9.5%, p = 0.223) did not show statistical significance. Tumor sizes measured in postoperative pathology were ~90% of those measured by preoperative US in PTC; this was not affected by tumor size, the presence of calcification or coexisting thyroiditis. When the surgical extent of PTC treatment according to tumor size measured by US is determined, the relative difference between tumor sizes measured by preoperative US and postoperative pathologic examination should be considered.
超声检查（US）是评估甲状腺结节大小和特征的有用诊断方法。肿瘤大小是甲状腺癌手术范围的关键指标。我们评估了术前 US 测量的肿瘤大小与甲状腺乳头状癌（PTC）术后病理检查的差异。我们回顾了 172 例连续接受甲状腺切除术治疗 PTC 的患者的病历。我们比较了术前 US 测量的肿瘤大小与术后标本的大小。并分析了一些可能影响大小测量的因素，包括癌症大小、钙化和并存的甲状腺炎。术前 US 测量的肿瘤平均大小为 11.4mm，术后病理检查为 10.2mm。术前 US 和术后病理检查测量的肿瘤大小的平均百分比差异（US-病理/US）为 9.9%±19.3%，差异具有统计学意义（p＜0.001）。当分析肿瘤大小（≤10.0mm vs. 10.1-20.0mm vs. ＞20.0mm）和钙化或并存的甲状腺炎对两种测量方法之间肿瘤大小差异的影响时，根据肿瘤大小（9.1%vs. 11.2%vs. 9.8%，p=0.842）、钙化（9.2%vs. 10.2%，p=0.756）和并存的甲状腺炎（17.6%vs. 9.5%，p=0.223）的平均百分比差异无统计学意义。在 PTC 中，术后病理测量的肿瘤大小约为术前 US 测量的 90%；这不受肿瘤大小、钙化存在或并存的甲状腺炎的影响。当根据术前 US 测量的肿瘤大小确定 PTC 治疗的手术范围时，应考虑术前 US 和术后病理检查测量的肿瘤大小之间的相对差异。
