Pan Yan, Tiong Kai Hung, Abd-Rashid Badrul Amini, Ismail Zakiah, Ismail Rusli, Mak Joon Wah, Ong Chin Eng
School of Medical Sciences, International Medical University, 126 Jalan 19/155B, Bukit Jalil, 57000, Kuala Lumpur, Malaysia.
J Nat Med. 2014 Apr;68(2):402-6. doi: 10.1007/s11418-013-0794-8. Epub 2013 Jul 24.
Eurycomanone, an active constituent isolated from Eurycoma longifolia Jack, was examined for modulatory effects on cytochrome P450 (CYP) isoforms CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2C19, CYP2E1 and CYP3A4 using in vitro assays. The IC50 value was determined to assess the potencies of modulation for each CYP isoform. Our results indicated that eurycomanone did not potently inhibit any of the CYP isoforms investigated, with IC50 values greater than 250 μg/ml. Hence there appears to be little likelihood of drug-herb interaction between eurycomanone or herbal products with high content of this compound and CYP drug substrates via CYP inhibition.
使用体外试验，研究了从长叶刺蒺藜中分离出的活性成分刺蒺藜酮对细胞色素P450（CYP）同工酶CYP1A2、CYP2A6、CYP2C8、CYP2C9、CYP2C19、CYP2E1和CYP3A4的调节作用。通过测定IC50值来评估每种CYP同工酶的调节效力。我们的结果表明，刺蒺藜酮对所研究的任何CYP同工酶均无显著抑制作用，IC50值大于250μg/ml。因此，刺蒺藜酮或含有高含量该化合物的草药产品与CYP药物底物之间似乎不太可能通过CYP抑制发生药物-草药相互作用。
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