Kato Yuji, Hayashi Takeshi, Kobayashi Toshiki, Tanahashi Norio
J Headache Pain. 2013 Jul 24;14(1):63. doi: 10.1186/1129-2377-14-63.
Patients with a patent foramen ovale have a high prevalence of migraine with aura (MA). However, whether patients with an atrial septal defect (ASD) have a high prevalence of migraine remains unclear. The present study aimed to determine the prevalence of migraine and its clinical characteristics in patients with ASD.
Ninety-five patients (age ≥ 20 years) who had undergone percutaneous ASD closure responded to a questionnaire used by neurologists to diagnose migraine either with or without aura. We diagnosed migraine before ASD closure according to the criteria of the International Headache Society. The overall prevalence of migraine seemed to be higher in the present study than in the Japanese general population (24.2% vs. 9.4%, respectively). All patients with MA were female and significantly younger than those without migraine (p < 0.01).
Our findings suggested that the susceptibility to the development of MA differs according to sex and age in patients with cardiac shunt.
卵圆孔未闭患者中伴先兆偏头痛（MA）的患病率较高。然而，房间隔缺损（ASD）患者中偏头痛的患病率是否较高仍不清楚。本研究旨在确定ASD患者中偏头痛的患病率及其临床特征。
95例年龄≥20岁且已接受经皮ASD封堵术的患者对神经科医生用于诊断有无先兆偏头痛的问卷进行了回答。我们根据国际头痛协会的标准在ASD封堵术前诊断偏头痛。本研究中偏头痛的总体患病率似乎高于日本普通人群（分别为24.2%和9.4%）。所有MA患者均为女性，且明显比无偏头痛患者年轻（p<0.01）。
我们的研究结果表明，心脏分流患者中MA发生的易感性因性别和年龄而异。
