Department of Radiology, Division of Nuclear Medicine, Stanford University Medical Center, 300 Pasteur Dr, Rm H-0101, Stanford, CA 94305, USA.
AJR Am J Roentgenol. 2013 Aug;201(2):W183-91. doi: 10.2214/AJR.12.8568.
Tumor growth and progression require the formation of new blood vessels from preexisting vasculature, a process called angiogenesis. The ability to noninvasively visualize angiogenesis may provide new opportunities to more appropriately select patients for antiangiogenesis treatment and to monitor treatment efficacy.
The superior molecular sensitivity of PET and the lack of radiation from MRI and contrast-enhanced ultrasound put these techniques at the forefront of clinical translation.
肿瘤的生长和进展需要从现有血管生成新的血管,这个过程称为血管生成。能够无创地可视化血管生成可能为更恰当地选择接受抗血管生成治疗的患者并监测治疗效果提供新的机会。
正电子发射断层扫描(PET)具有更高的分子灵敏度,磁共振成像(MRI)和对比增强超声没有辐射,这些技术处于临床转化的前沿。