Nunes Renata Portella, Gregori Giovanni, Yehoshua Zohar, Stetson Paul F, Feuer William, Moshfeghi Andrew A, Rosenfeld Philip J
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, Miami, Florida 33136, USA.
Ophthalmic Surg Lasers Imaging Retina. 2013 Jul-Aug;44(4):344-59. doi: 10.3928/23258160-20130715-06.
Spectral-domain optical coherence tomography (SD-OCT) en face imaging was used to measure the growth of geographic atrophy (GA) and identify baseline anatomic changes in the outer retina in eyes with nonexudative age-related macular degeneration (AMD).
In this prospective study, eyes were imaged using 200 × 200 and 512 × 128 A-scan raster patterns. Outer retinal anatomy was visualized using en face imaging of a 20-μm thick slab encompassing the inner segment/outer segment (IS/OS) band.
En face SD-OCT imaging of the IS/OS region revealed a bilaterally symmetrical pattern of outer retinal disruption extending beyond the borders of GA that accurately predicted the progression of GA over 1 year in 13 of 30 eyes (43.3%). In the remaining cases, the area of disruption was much larger than the area of progression.
En face imaging of the outer retina can predict the growth of GA in some eyes. Due to the bilateral symmetry of these findings, this imaging strategy may identify a genetic subset of patients in whom photoreceptor loss precedes the progression of GA. These areas with outer retinal disruption should be followed in clinical trials designed to test treatments for dry AMD.
采用频域光学相干断层扫描（SD-OCT）的正面成像技术来测量地图样萎缩（GA）的进展情况，并识别非渗出性年龄相关性黄斑变性（AMD）患者眼外视网膜的基线解剖学变化。
在这项前瞻性研究中，使用200×200和512×128 A扫描光栅模式对眼睛进行成像。通过对包含内节/外节（IS/OS）带的20μm厚平板进行正面成像来观察外视网膜解剖结构。
IS/OS区域的SD-OCT正面成像显示，外视网膜破坏呈双侧对称模式，其范围超出GA边界，在30只眼中有13只（43.3%）准确预测了GA在1年内的进展情况。在其余病例中，破坏区域远大于进展区域。
外视网膜正面成像可在部分眼中预测GA的进展。鉴于这些发现具有双侧对称性，这种成像策略可能识别出在GA进展之前存在光感受器丢失的患者遗传亚组。在旨在测试干性AMD治疗方法的临床试验中，应对这些存在外视网膜破坏的区域进行随访。
