Vernon H J, Lane A T, Wischerath L J, Davis J M, Menegus M A
Department of Dermatology, University of Rochester School of Medicine and Dentistry, New York.
Pediatrics. 1990 Sep;86(3):357-62.
Within the first days of life, 10 infants, of 32 weeks' gestational age or less, began 2 weeks of treatment with a semipermeable wound dressing over a small area of skin. The effects of the dressing on transepidermal water loss and cutaneous microflora were evaluated. Transepidermal water loss from the semipermeable dressing-treated skin was significantly less than that from the untreated skin immediately after placement of the dressing (8.1 +/- 1.8 g/m2.h-1 vs 17.7 +/- 3.5 g/m2.h-1, P less than .0001). The normal accelerated skin maturation process that occurs in these infants continued beneath the semipermeable dressing. The number of gram-negative bacilli or other bacteria did not increase beneath the semipermeable dressing beyond that seen on the untreated site. Malassezia furfur was found only on the control site, never beneath the semipermeable dressing. According to results of this preliminary study, a semipermeable dressing can be safely used in premature infants and the use of a semipermeable dressing may decrease the excessive transepidermal water loss associated with prematurity.
在出生后的头几天，10名孕周为32周或更小的婴儿开始在一小片皮肤上使用半透性伤口敷料进行为期2周的治疗。评估了该敷料对经表皮水分流失和皮肤微生物群的影响。在放置敷料后立即测量，经半透性敷料处理的皮肤的经表皮水分流失明显低于未处理的皮肤（8.1±1.8克/平方米·小时对17.7±3.5克/平方米·小时，P＜0.0001）。在这些婴儿中正常发生的加速皮肤成熟过程在半透性敷料下持续进行。在半透性敷料下革兰氏阴性杆菌或其他细菌的数量没有超过未处理部位的数量。糠秕马拉色菌仅在对照部位发现，从未在半透性敷料下发现。根据这项初步研究的结果，半透性敷料可安全用于早产儿，并且使用半透性敷料可能会减少与早产相关的过多经表皮水分流失。
