Mealey Katrina L
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164-6610, USA.
Vet Clin North Am Small Anim Pract. 2013 Sep;43(5):1067-78. doi: 10.1016/j.cvsm.2013.04.004. Epub 2013 Jun 2.
For many drugs used in veterinary practice, plasma and tissue concentrations are highly dependent on the activity of drug transporters. This article describes how functional changes in drug transporters, whether mediated by genetic variability or drug-drug interactions, affect drug disposition and, ultimately, drug safety and efficacy in veterinary patients. A greater understanding of species, breed, and individual (genetic) differences in drug transporter function, as well as drug-drug interactions involving drug transporters, will result in improved strategies for drug design and will enable veterinarians to incorporate individualized medicine in their practices.
对于许多兽医临床使用的药物，血浆和组织浓度高度依赖于药物转运体的活性。本文描述了药物转运体的功能变化（无论由基因变异还是药物相互作用介导）如何影响药物处置，并最终影响兽医患者的药物安全性和有效性。深入了解药物转运体功能在物种、品种和个体（基因）方面的差异，以及涉及药物转运体的药物相互作用，将有助于改进药物设计策略，并使兽医能够在临床实践中采用个体化医疗。
