Department of Molecular and Cell Biology, University of California, Berkeley, United States.
Curr Opin Cell Biol. 2013 Dec;25(6):704-10. doi: 10.1016/j.ceb.2013.07.004. Epub 2013 Jul 24.
Recent work revealed that cullin-RING ligases and the anaphase-promoting complex, two classes of ubiquitin ligases that are essential for cell division in all eukaryotes, are regulated in a highly dynamic manner. Here, we describe mechanisms that establish the dynamic regulation of these crucial ubiquitylation enzymes and discuss the functional consequences for cell division control.
最近的研究揭示，泛素连接酶家族中的两个重要分支——Cullin-RING 连接酶和后期促进复合物（anaphase-promoting complex，APC），对于所有真核生物的细胞分裂都是必不可少的，它们的活性受到高度动态的调控。本文将介绍建立这些关键泛素化酶的动态调控机制，并讨论其对细胞分裂控制的功能后果。
