Tsujimura Akira
Department of Urology, Osaka University Graduate School of Medicine, Japan.
Clin Calcium. 2013 Aug;23(8):1185-90.
Androgen deprivation therapy has been considered as one of useful treatment options for prostate cancer. However, it presents several symptoms of "castration syndrome" as side effects, based on low serum testosterone concentration. The symptoms includes loss of libido and sexual interest, erectile dysfunction, general fatigue, decreased intellectual ability, depression, loss of muscle strength, increased abdominal fat mass, and loss of vigor. They are almost similar to the representative symptoms of late onset hypogonadism. Furthermore, side effects such as increased risk of fracture and metabolic syndrome caused by androgen deprivation therapy should be taken care, even though subjective complaints do not appear.
雄激素剥夺疗法一直被认为是前列腺癌的有效治疗选择之一。然而，基于血清睾酮浓度低，它会出现几种“去势综合征”症状作为副作用。这些症状包括性欲和性兴趣丧失、勃起功能障碍、全身疲劳、智力下降、抑郁、肌肉力量丧失、腹部脂肪量增加和活力丧失。它们几乎与迟发性性腺功能减退的典型症状相似。此外，即使没有出现主观不适，也应注意雄激素剥夺疗法引起的骨折风险增加和代谢综合征等副作用。
