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清晰呈现肾细胞癌。

A clear picture of renal cell carcinoma.

出版信息

Nat Genet. 2013 Aug;45(8):849-50. doi: 10.1038/ng.2708.

DOI:10.1038/ng.2708
PMID:23892664
Abstract

Two recent studies describe the largest molecular profiling analyses to date of clear-cell renal cell carcinoma (ccRCC) and report remarkably similar findings. The recurrent pathway alterations identified in these studies open new avenues for therapeutic advances in this chemotherapy- and radiation-resistant disease.

摘要

最近两项研究描述了迄今为止最大的透明细胞肾细胞癌(ccRCC)的分子分析,并报告了非常相似的发现。这些研究中确定的复发性途径改变为这种对化疗和放疗有抵抗力的疾病的治疗进展开辟了新的途径。

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Comprehensive molecular characterization of clear cell renal cell carcinoma.透明细胞肾细胞癌的全面分子特征分析。
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S100A2通过调节GLUT2表达促进肾透明细胞癌肿瘤转移。
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Protein kinase CK2 sustains de novo fatty acid synthesis by regulating the expression of SCD-1 in human renal cancer cells.蛋白激酶CK2通过调节人肾癌细胞中SCD-1的表达来维持从头脂肪酸合成。
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Whole genome sequencing refines stratification and therapy of patients with clear cell renal cell carcinoma.全基因组测序细化了透明细胞肾细胞癌患者的分层和治疗。
Nat Commun. 2024 Jul 15;15(1):5935. doi: 10.1038/s41467-024-49692-1.
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PSAT1 enhances the efficacy of the prognosis estimation nomogram model in stage-based clear cell renal cell carcinoma.PSAT1 增强了基于分期的透明细胞肾细胞癌预后评估列线图模型的疗效。
BMC Cancer. 2024 Apr 13;24(1):463. doi: 10.1186/s12885-024-12183-z.
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Boosting Clear Cell Renal Carcinoma-Specific Drug Discovery Using a Deep Learning Algorithm and Single-Cell Analysis.利用深度学习算法和单细胞分析技术促进透明细胞肾细胞癌的特异性药物研发。
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